Evidence map›Paper›PMID 35058316›Full record

ArticleJournal of neurointerventional surgery2023

Influence of the interventionist's experience on outcomes of endovascular thrombectomy in acute ischemic stroke: results from the MR CLEAN Registry.

Susanne G H Olthuis, Sanne J den Hartog, Sander M J van Kuijk, Julie Staals, Faysal Benali, Christiaan van der Leij, Debbie Beumer, Geert J Lycklama À Nijeholt, Maarten Uyttenboogaart, Jasper M Martens and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurointerventional surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. The effect of operator's experience on mechanical thrombectomy outcomes: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Susanne G H OlthuisDepartment of Neurology, Maastricht University Medical Center+, Maastricht, The Netherlands susan.olthuis@mumc.nl.ORCID http://orcid.org/0000-0002-2802-1511
Sanne J den HartogDepartment of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1650-951X
Sander M J van KuijkDepartment of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, The Netherlands.
Julie StaalsDepartment of Neurology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Faysal BenaliMaastricht University CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-1043-1125
Christiaan van der LeijMaastricht University CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.
Debbie BeumerDepartment of Neurology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Geert J Lycklama À NijeholtDepartment of Radiology, Medical Center Haaglanden, The Haque, The Netherlands.
Maarten UyttenboogaartDepartment of Neurology and Medical Imaging Center, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-6934-4456
Jasper M MartensDepartment of Radiology, Rijnstate Hospital, Arnhem, The Netherlands.
Pieter-Jan van DoormaalDepartment of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Jan Albert VosDepartment of Radiology, Sint Antonius Hospital, Nieuwegein, The Netherlands.
Bart J EmmerDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Diederik W J DippelDepartment of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9234-3515
Wim H van ZwamMaastricht University CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-1631-7056
Robert J van OostenbruggeDepartment of Neurology, Maastricht University Medical Center+, Maastricht, The Netherlands.
Inger R de RidderDepartment of Neurology, Maastricht University Medical Center+, Maastricht, The Netherlands.
MR CLEAN Registry investigators
Maastricht University · NLErasmus MC · NLMaastricht University Medical Centre · NLMedisch Centrum Haaglanden · NLRijnstate Hospital · NLSt. Antonius Ziekenhuis · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between the interventionist's experience and outcomes of endovascular thrombectomy (EVT) for acute ischemic stroke of the anterior circulation, is unclear.

objectiveTo assess the effect of the interventionist's level of experience on clinical, imaging, and workflow outcomes. Secondly, to determine which of the three experience definitions is most strongly associated with these outcome measures.

methodsWe analysed data from 2700 patients, included in the MR CLEAN Registry. We defined interventionist's experience as the number of procedures performed in the year preceding the intervention (EXPfreq), total number of procedures performed (EXPno), and years of experience (EXPyears). Our outcomes were the baseline-adjusted National Institutes of Health Stroke Scale (NIHSS) score at 24-48 hours post-EVT, recanalization (extended Thrombolysis in Cerebral Infarction (eTICI) score ≥2B), and procedural duration. We used multilevel regression models with interventionists as random intercept. For EXPfreq and EXPno results were expressed per 10 procedures.

resultsIncreased EXPfreq was associated with lower 24-48 hour NIHSS scores (adjusted (a)β:-0.46, 95% CI -0.70 to -0.21). EXPno and EXPyears were not associated with short-term neurological outcomes. Increased EXPfreq and EXPno were both associated with recanalization (aOR=1.20, 95% CI 1.11 to 1.31 and aOR=1.08, 95% CI 1.04 to 1.12, respectively), and increased EXPfreq, EXPno, and EXPyears were all associated with shorter procedure times (aβ:-3.08, 95% CI-4.32 to -1.84; aβ:-1.34, 95% CI-1.84 to -0.85; and aβ:-0.79, 95% CI-1.45 to -0.13, respectively).

conclusionsHigher levels of interventionist's experience are associated with better outcomes after EVT, in particular when experience is defined as the number of patients treated in the preceding year. Every 20 procedures more per year is associated with approximately one NIHSS score point decrease, an increased probability for recanalization (aOR=1.44), and a 6-minute shorter procedure time.

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeHumansRegistriesThrombectomyTreatment Outcomeinterventionstrokethrombectomy

Identifiers

PMID35058316
PMCPMC9872238
OpenAlexW4206306013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.