Observational studyArchives of disease in childhood. Fetal and neonatal edition2022
Associations of body composition with regional brain volumes and white matter microstructure in very preterm infants.
Observational study in Archives of disease in childhood. Fetal and neonatal edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Association between postnatal anthropometric growth by term and high-performing neurodevelopment at age 3 years in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age.Pediatric research · 2026Article
- Towards improving outcomes: Protein, body composition, and brain development in preterm infants.Pediatric research · 2026Article
- Associations of human milk lactoferrin with measures of physical growth in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Increasing length board use in a neonatal intensive care unit: a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal steroid exposure and body composition in preterm infants at discharge.Pediatric research · 2026Article
- Accuracy and reliability of bioelectrical impedance analysis for determining body composition among preterm infants.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Article
- Standardizing Neonatal Body Composition Assessment Using Air Displacement Plethysmography: Insights from the Bavarian Experience.Children (Basel, Switzerland) · 2025Article
- Establishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants.Pediatric research · 2024Article
- Lactoferrin intake from maternal milk during the neonatal hospitalization and early brain development among preterm infants.Pediatric research · 2024Article
- Impact of Nutritional Status on Total Brain Tissue Volumes in Preterm Infants.Children (Basel, Switzerland) · 2024Article
- Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Review
- Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age.Scientific reports · 2023Article
- Novel metrics to characterize temporal lobe of very preterm infants on term-equivalent brain MRI.Pediatric research · 2023Article
- Article
- Body composition measurement for the preterm neonate: using a clinical utility framework to translate research tools into clinical care.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo determine associations between body composition and concurrent measures of brain development including (1) Tissue-specific brain volumes and (2) White matter microstructure, among very preterm infants at term equivalent age.
designProspective observational study.
settingSingle-centre academic level III neonatal intensive care unit. PATIENTS: We studied 85 infants born <33 weeks' gestation.
methodsAt term equivalent age, infants underwent air displacement plethysmography to determine body composition, and brain MRI from which we quantified tissue-specific brain volumes and fractional anisotropy (FA) of white matter tracts. We estimated associations of fat and lean mass Z-scores with each brain outcome, using linear mixed models adjusted for intrafamilial correlation among twins and potential confounding variables.
resultsMedian gestational age was 29 weeks (range 23.4-32.9). One unit greater lean mass Z-score was associated with larger total brain volume (10.5 cc, 95% CI 3.8 to 17.2); larger volumes of the cerebellum (1.2 cc, 95% CI 0.5 to 1.9) and white matter (4.5 cc, 95% CI 0.7 to 8.3); and greater FA in the left cingulum (0.3%, 95% CI 0.1% to 0.6%), right uncinate fasciculus (0.2%, 95% CI 0.0% to 0.5%), and right posterior limb of the internal capsule (0.3%, 95% CI 0.03% to 0.6%). Fat Z-scores were not associated with any outcome.
conclusionsLean mass-but not fat-at term was associated with larger brain volume and white matter microstructure differences that suggest improved maturation. Lean mass accrual may index brain growth and development.
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Registered trials
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