Evidence map›Paper›PMID 35058256›Full record

ArticleBMJ open2022

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.

Kylie E Hunter, Brittany J Johnson, Lisa Askie, Rebecca K Golley, Louise A Baur, Ian C Marschner, Rachael W Taylor, Luke Wolfenden, Charles T Wood, Seema Mihrshahi and 51 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Interventions to prevent obesity in children aged 2 to 4 years old.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Supporting Decision Making in Early Years Initiatives: Co-Designing a Child Health Evidence Dashboard.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2026
    Article
  7. A Scoping Review of Instruments Used to Measure Weight and Body Composition in Infants Under 1 Year.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Child and adolescent obesity.Nature reviews. Disease primers · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors.

Kylie E HunterNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia kylie.hunter@sydney.edu.au.ORCID 0000-0002-2796-9220
Brittany J JohnsonCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0001-5492-9219
Lisa AskieNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Rebecca K GolleyCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
Louise A BaurChildren's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia.
Ian C MarschnerNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Rachael W TaylorDepartment of Medicine, University of Otago, Dunedin, New Zealand.
Luke WolfendenSchool of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
Charles T WoodSchool of Medicine, Duke University, Durham, North Carolina, USA.
Seema MihrshahiDepartment of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Alison J HayesSchool of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Chris RisselSchool of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Kristy P RobledoNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Denise A O'ConnorDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-6836-122X
David EspinozaNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Lukas P StaubNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Paul ChadwickCentre For Behaviour Change, University College London, London, UK.
Sarah TakiSchool of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Angie BarbaNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Sol LibesmanNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Mason AberoumandNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Wendy A SmithCanterbury Community Health Centre, Sydney Local Health District, Campsie, New South Wales, Australia.
Michelle Sue-SeeConsumer Representative, Sydney, New South Wales, Australia.
Kylie D HeskethInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-2702-7110
Jessica L ThomsonAgricultural Research Service, USDA, Stoneville, Mississippi, USA.
Maria BryantDepartment of Health Sciences and the Hull York Medical School, University of York, York, UK.
Ian M PaulPenn State College of Medicine, Hershey, Pennsylvania, USA.
Vera VerbestelDepartment of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Cathleen Odar StoughDepartment of Psychology, University of Cincinnati, Cincinnati, Ohio, USA.
Li Ming WenSchool of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Junilla K LarsenBehavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
Sharleen L O'ReillySchool of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
Heather M WasserDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer S SavageDepartment of Nutritional Sciences & Center for Childhood Obesity Research, Pennsylvania State University, University Park, Pennsylvania, USA.
Ken K OngMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Sarah-Jeanne SalvyResearch Center for Health Equity, Cedars-Sinai Medical Center, West Hollywood, California, USA.
Mary Jo MessitoGrossman School of Medicine, New York University, New York, New York, USA.
Rachel S GrossGrossman School of Medicine, New York University, New York, New York, USA.
Levie T KarssenBehavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
Finn E RasmussenDepartment of Global Public Health, Karolinska Institute, Stockholm, Sweden.
Karen CampbellInstitute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
Ana Maria LinaresCollege of Nursing, University of Kentucky, Lexington, Kentucky, USA.
Nina Cecilie ØverbyFaculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway.ORCID 0000-0002-1871-041X
Cristina PalaciosDepartment of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA.
Kaumudi J JoshipuraDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Carolina González AceroSocial Protection and Health Division, Inter-American Development Bank, Santo Domingo, Distrito Nacional, Dominican Republic.
Rajalakshmi LakshmanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Amanda L ThompsonDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Claudio MaffeisPediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Ata GhaderiDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Maribel Campos RiveraMedical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, USA.
Ana B Pérez-ExpósitoSocial Protection and Health Division, Inter-American Development Bank, Washington, District of Columbia, USA.
Jinan C BannaDepartment of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, Hawaii, USA.
Kayla de la HayeDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Michael GoranDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Margrethe RøedFaculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway.
Stephanie Anzman-FrascaDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Barry J TaylorBetter Start National Science Challenge, University of Otago, Dunedin, New Zealand.
Anna Lene SeidlerNHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-0027-1623
Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Abiel Roche-Lima · 2017 to 2026
$35.8M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Project 2: Leveraging Ongoing Home Visitation Programs to Address Obesity Disparities among Underserved, Low-Income Mothers and ChildrenU54MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SALVY, SARAH-JEANNE · 2017 to 2022
$11.8M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Preventing Obesity through Intervention during InfancyR01DK088244 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PAUL, IAN M, WILLIAMS, JENNIFER SAVAGE · 2011 to 2022
$7.0M
Breastfeeding RCT: Adolescent Neurocognitive and Respiratory FunctionR01HD050758 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI MARTIN, RICHARD MICHAEL, OKEN, EMILY · 2007 to 2014
$3.0M
Mothers and Others: Family-based Obesity Prevention for Infants and ToddlersR01HD073237 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENTLEY, MARGARET E · 2012 to 2016
$2.9M
In-home obesity prevention to reach low-income infants through maternal and social transmissionR01HD092483 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DE LA HAYE, KAYLA, SALVY, SARAH-JEANNE · 2017 to 2021
$2.7M
Addressing Poverty-Related Barriers to Prevent Obesity Beginning in InfancyK23HD081077 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON · 2014 to 2018
$653k
CIHR MOP-53155Medical Research Council MC_EX_G0701655Medical Research Council MC_EX_MR/J000361/1Medical Research Council MC_EX_UU_MR/J000361/1Medical Research Council MC_UU_00006/2Medical Research Council MR/J000361/1NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NICHD NIH HHS K23 HD081077NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD050758NICHD NIH HHS R01 HD073237NICHD NIH HHS R01 HD092483NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK088244NIMHD NIH HHS U54 MD000502NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

introductionBehavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. METHODS AND ANALYSIS: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. ETHICS AND DISSEMINATION: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO REGISTRATION NUMBER: CRD42020177408.

Indexed as

Pediatric ObesityBehavior TherapyBody Mass IndexChildChild, PreschoolExerciseHumansInfantMeta-Analysis as TopicProspective StudiesSystematic Reviews as Topiccommunity child healthpaediatricspreventive medicinepublic health

Identifiers

PMID35058256
PMCPMC8783820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.