Evidence map›Paper›PMID 35058150›Full record

ArticleTrends in immunology2022

Th17 cells: from gut homeostasis to CNS pathogenesis.

Jane H Buckner, Oliver J Harrison

Open access · greenAbstract readComment
In one paragraph

Article in Trends in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Dissecting PGENature communications · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jane H BucknerCenter for Translational Immunology, Benaroya Research Institute, 1201 9th Ave, Seattle, WA 98101, USA; Department of Immunology, University of Washington, 750 Republican St., Seattle, WA 98108, USA. Electronic address: jbuckner@benaroyaresearch.org.
Oliver J HarrisonDepartment of Immunology, University of Washington, 750 Republican St., Seattle, WA 98108, USA; Center for Fundamental Immunology, Benaroya Research Institute, 1201 9th Ave, Seattle, WA 98101, USA.
Center for Infectious Disease Research · USInstitute of Translational Health Sciences · US

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
Defining the role of altered cytokine signaling pathways on autoimmunityU01AI101990 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2016
$12.1M
Mechanisms of IL-6 mediated T cell pathogenesis in autoimmunityR01AI132774 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2017 to 2020
$6.4M
Prevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid ArthritisU01AI101981 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2012 to 2021
$6.2M
Unmodified and Post Translationally Modified CD4+ and CD8+ T cell Epitopes in Rheumatoid Arthritis75N93019C00068 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BENTON, RYAN · 2019 to 2023
$5.4M
Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapyR01CA231226 · NCI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT, LINSLEY, PETER S · 2019 to 2024
$5.1M
Commensal-specific T cell function in skin wound repairR01AI158624 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HARRISON, OLIVER JAMES · 2021 to 2025
$2.9M
NCI NIH HHS R01 CA231226NIAID NIH HHS 75N93019C00068NIAID NIH HHS R01 AI132774NIAID NIH HHS R01 AI158624NIAID NIH HHS U01 AI101981NIAID NIH HHS U01 AI101990NIAID NIH HHS UM1 AI109565
6 · The paper itself

Abstract

Th17 cells play crucial roles in host-microbe interactions, but can also promote chronic inflammation and tissue pathology. Factors influencing Th17 cell heterogeneity and effector functions in different inflammatory contexts remain unclear. Schnell et al. demonstrate that intestinal Th17 cells form a reservoir from which pathogenic Th17 cells can be elicited during severe tissue inflammation.

Indexed as

InflammationTh17 CellsHomeostasisHumans

Identifiers

PMID35058150
PMCPMC10029755
OpenAlexW4205149835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.