Evidence map›Paper›PMID 35057913›Full record

ArticleJournal of the American College of Cardiology2022

Rural-Urban Disparities in Outcomes of Myocardial Infarction, Heart Failure, and Stroke in the United States.

Eméfah C Loccoh, Karen E Joynt Maddox, Yun Wang, Dhruv S Kazi, Robert W Yeh, Rishi K Wadhera

Abstract readComparative Study
In one paragraph

Article in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Post-Intensive Care Fragmentation Among Rural Veterans: Transitions Between VA and Community Health Systems.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Eméfah C LoccohRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Karen E Joynt MaddoxCardiovascular Division, Washington University School of Medicine, Saint Louis, Missouri, USA.
Yun WangRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA.
Dhruv S KaziRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA.
Robert W YehRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA.
Rishi K WadheraRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rwadhera@bidmc.harvard.edu.

Funding

Use of Registries, Claims and Health System Data to Enhance the Evaluation of Cardiovascular Therapies in Clinical TrialsR01HL136708 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Issa J. Dahabreh, Robert Yeh · 2017 to 2026
$6.9M
The Impact of Bundled Payments for Cardiopulmonary Disease on High-Risk PopulationsR01HL143421 · NHLBI · WASHINGTON UNIVERSITY · PI JOYNT MADDOX, KAREN ELLEN · 2019 to 2022
$3.1M
A Multi-Dimensional Linked Registry to Identify Biological, Clinical, Health System, and Socioeconomic Risk Factors for COVID-19-Related Cardiovascular EventsR01HL157530 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GERSZTEN, ROBERT E, KAZI, DHRUV SATISH · 2021 to 2024
$3.0M
Improving the Quality of Care Provided Through Bundled Payments for Patients with Alzheimer's Disease or Other Forms of Dementia or FrailtyR01AG060935 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI EPSTEIN, ARNOLD, JOYNT MADDOX, KAREN ELLEN · 2019 to 2021
$2.7M
Explaining Rising Heart Failure Mortality in MedicareK23HL148525 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WADHERA, RISHI KUMAR · 2019 to 2023
$863k
NHLBI NIH HHS K23 HL148525NHLBI NIH HHS R01 HL136708NHLBI NIH HHS R01 HL143421NHLBI NIH HHS R01 HL157530NIA NIH HHS R01 AG060935
6 · The paper itself

Abstract

backgroundU.S. policy efforts have focused on reducing rural-urban health inequities. However, it is unclear whether gaps in care and outcomes remain among older adults with acute cardiovascular conditions.

objectivesThis study aims to evaluate rural-urban differences in procedural care and mortality for acute myocardial infarction (AMI), heart failure (HF), and ischemic stroke.

methodsThis is a retrospective cross-sectional study of Medicare fee-for-service beneficiaries aged ≥65 years with acute cardiovascular conditions from 2016 to 2018. Cox proportional hazards models with random hospital intercepts were fit to examine the association of presenting to a rural (vs urban) hospital and 30- and 90-day patient-level mortality.

resultsThere were 2,182,903 Medicare patients hospitalized with AMI, HF, or ischemic stroke from 2016 to 2018. Patients with AMI were less likely to undergo cardiac catherization (49.7% vs 63.6%, P < 0.001), percutaneous coronary intervention (42.1% vs 45.7%, P < 0.001) or coronary artery bypass graft (9.0% vs 10.2%, P < 0.001) within 30 days at rural versus urban hospitals. Thrombolysis rates (3.1% vs 10.1%, P < 0.001) and endovascular therapy (1.8% vs 3.6%, P < 0.001) for ischemic stroke were lower at rural hospitals. After adjustment for demographics and clinical comorbidities, the 30-day mortality HR was significantly higher among patients presenting to rural hospitals for AMI (HR: 1.10, 95% CI: 1.08 to 1.12), HF (HR: 1.15; 95% CI: 1.13 to 1.16), and ischemic stroke (HR: 1.20; 95% CI: 1.18 to 1.22), with similar patterns at 90 days. These differences were most pronounced for the subset of critical access hospitals that serve remote, rural areas.

conclusionsClinical, public health, and policy efforts are needed to improve rural-urban gaps in care and outcomes for acute cardiovascular conditions.

Indexed as

Healthcare DisparitiesAgedAged, 80 and overCardiac CatheterizationCoronary Artery BypassCross-Sectional StudiesEndovascular ProceduresHeart FailureHospitals, RuralHospitals, UrbanHumansMaleMedicareMyocardial InfarctionPercutaneous Coronary InterventionRetrospective Studiescardiovascularhealth disparitiesheart failuremyocardial infarctionrural healthstroke

Identifiers

PMID35057913
PMCPMC8958031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.