Evidence map›Paper›PMID 35057837›Full record

ArticleTrials2022

The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age).

Eleanor J Mitchell, Garry Meakin, Josie Anderson, Jon Dorling, Chris Gale, Rachel Haines, Charlotte Kenyan, Mark J Johnson, William McGuire, Hema Mistry and 7 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Early and exclusive enteral nutrition in infants born very preterm.Archives of disease in childhood. Fetal and neonatal edition · 2024
    Trial
  4. Article
  5. Review
  6. Does early high-volume enteral feeding initiation increase the total days on full feeds in very preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Eleanor J MitchellNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK. eleanor.mitchell@nottingham.ac.uk.ORCID http://orcid.org/0000-0002-6998-4533
Garry MeakinNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Josie AndersonBliss, 4th Floor Maya House, 134-138 Borough High Street, London, SE1 1LB, UK.
Jon DorlingDepartment of Neonatal Medicine, University Hospital Southampton NHS Foundation Trust and NIHR Biomedical research Centre Southampton, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, SO16 6YD, UK.
Chris GaleNeonatal Medicine, School of Public Health, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital campus, London, SW10 9NH, UK.
Rachel HainesNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Charlotte Kenyanc/o Nottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Mark J JohnsonDepartment of Neonatal Medicine, University Hospital Southampton NHS Foundation Trust and NIHR Biomedical research Centre Southampton, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, SO16 6YD, UK.
William McGuireCentre for Reviews and Dissemination, University of York, A/B Block, Alcuin College, York, YO10 5DD, UK.
Hema MistryWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Alan MontgomeryNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Sam OddieDepartment of Neonatal Medicine, Bradford Teaching Hospitals NHS Foundation Trust, Duckworth Lane, Bradford, BD9 6RJ, UK.
Reuben OgollahNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Phoebe PallottiDivision of Midwifery, School of Health Sciences, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Christopher PartlettNottingham Clinical Trials Unit, Building 42, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
Kate F WalkerPopulation and Applied Health Sciences, School of Medicine University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Shalini OjhaPopulation and Applied Health Sciences, School of Medicine University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
University of Nottingham · GBUniversity Hospital Southampton NHS Foundation Trust · GBBliss · GBBradford Teaching Hospitals NHS Foundation Trust · GBChelsea and Westminster Hospital · GBUniversity of Warwick · GBUniversity of York · GB

Funding

Health Technology Assessment Programme 17/94/31
6 · The paper itself

Abstract

backgroundIn the UK, approximately 8% of live births are preterm (before 37 weeks gestation), more than 90% of whom are born between 30 and 36 weeks, forming the largest proportion of a neonatal units' workload. Neonatologists are cautious in initiating full milk feeds for preterm infants due to fears of necrotising enterocolitis (NEC). There is now evidence to dispute this fear. Small studies have shown that feeding preterm infants full milk feeds enterally from birth could result in a shorter length of hospital stay, which is important to parents, clinicians and NHS services without increasing the risk of NEC. This trial aims to investigate whether full milk feeds initiated in the first 24 h after birth reduces the length of hospital stay in comparison to introduction of gradual milk feeding with IV fluids or parenteral nutrition.

methodsFEED1 is a multi-centre, open, parallel group, randomised, controlled superiority trial of full milk feeds initiated on the day of birth versus gradual milk feeds for infants born at 30 DISCUSSION: This trial will provide high-quality evidence on feeding practices for preterm infants. Full milk feeds from day of birth could result in infants being discharged sooner.

trial registrationISRCTN ISRCTN89654042 . Prospectively registered on 23 September 2019: ISRCTN is a primary registry of the WHO ICTRP network, and all items from the WHO Trial Registration dataset are included.

Indexed as

AftercareInfant, PrematureEnteral NutritionEquivalence Trials as TopicFemaleGestational AgeHumansInfantInfant, NewbornMilk, HumanMulticenter Studies as TopicPatient DischargeRandomized Controlled Trials as TopicClinical trialEnteral feedingFeedingFull milkNeonatalPreterm infantProtocol

Identifiers

PMID35057837
PMCPMC8780243
OpenAlexW4206565893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.