Evidence map›Paper›PMID 35057802›Full record

ArticleBMC veterinary research2022

Holoprosencephalia, hypoplasia of corpus callosum and cerebral heterotopia in a male belted Galloway heifer with adipsia.

Jasmin Nessler, Christian Wunderlich, Deborah Eikelberg, Andreas Beineke, Jonathan Raue, Martin Runge, Andrea Tipold, Martin Ganter, Jürgen Rehage

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jasmin Nessler *Department for Small Animal Internal Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, Buenteweg 9, 30559, Hannover, Germany. jasmin.nessler@tiho-hannover.de.ORCID http://orcid.org/0000-0002-1427-2555
Christian Wunderlich *Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hannover, Germany.
Deborah EikelbergInstitute for Pathology, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559, Hannover, Germany.
Andreas BeinekeInstitute for Pathology, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559, Hannover, Germany.
Jonathan RaueDepartment for Small Animal Internal Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, Buenteweg 9, 30559, Hannover, Germany.
Martin RungeLower Saxony State Office for Consumer Protection and Food Safety Food and Veterinary Institute Braunschweig/Hannover, Eintrachtweg 17, 30173, Hannover, Germany.
Andrea TipoldDepartment for Small Animal Internal Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, Buenteweg 9, 30559, Hannover, Germany.
Martin GanterClinic for Swine, Small Ruminants and Forensic Medicine, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hannover, Germany.
Jürgen RehageClinic for Cattle, University of Veterinary Medicine Vienna (Vetmeduni Vienna), Veterinaerplatz 1, A-1210, Vienna, Austria.
University of Veterinary Medicine Hannover, Foundation · DELower Saxony State Office for Consumer Protection and Food Safety · DEUniversity of Veterinary Medicine Vienna · AT

Funding

Deutsche Forschungsgemeinschaft Open Access Publication FundStiftung Tierärztliche Hochschule Hannover Open Access Publication Fund
6 · The paper itself

Abstract

backgroundSpecialized neurons in the diencephalon detect blood hypernatremia in dehydrated animals. These neurons are connected with the pituitary gland, subsequently producing antidiuretic hormone to reabsorb water from urine in the kidneys, and to the forebrain to generate thirst and trigger drinking behavior. CASE PRESENTATION: This is the first case report describing clinical findings, magnetic resonance imaging (MRI) and necropsy results of a Belted Galloway heifer with severe clinical signs of dehydration and hypernatremia, but concurrent adipsia and isosthenuria. Due to insufficient recovery with symptomatic treatment, owners elected euthanasia. Postmortem MRI and necropsy revealed a complex forebrain malformation: mild abnormal gyrification of the forebrain cortex, lobar holoprosencephaly, and corpus callosum hypoplasia. The affected brain structures are well known to be involved in osmoregulation and generation of thirst in dogs, humans and rodents.

conclusionsComplex forebrain malformation can be involved in the pathogenesis of hypernatremia and adipsia in bovines.

Indexed as

Cattle DiseasesHypernatremiaAnimalsBrainCattleCorpus CallosumFemaleThirstCattleDrinkingEncephalopathyHypernatremiaMalformationNeurological disorderThirst

Identifiers

PMID35057802
PMCPMC8772152
OpenAlexW4206528148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.