Evidence map›Paper›PMID 35057754›Full record

ArticleBMC infectious diseases2022

Predictors of treatment outcomes among patients with multidrug-resistant tuberculosis in Vietnam: a retrospective cohort study.

Ian Wrohan, Thu Anh Nguyen, Viet Nhung Nguyen, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Phuong Chi Nguyen, Kavindhran Velen, Guy Barrington Marks, Greg James Fox

Abstract read
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In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Rifampicin resistantJournal of clinical tuberculosis and other mycobacterial diseases · 2024
    Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ian WrohanThe Central Clinical School, Faculty of Medicine and Health, The University of Sydney, 90-92 Parramatta Road, Sydney, NSW, 2006, Australia. iwrohan@gmail.com.
Thu Anh NguyenThe Central Clinical School, Faculty of Medicine and Health, The University of Sydney, 90-92 Parramatta Road, Sydney, NSW, 2006, Australia.
Viet Nhung NguyenNational Lung Hospital, Hanoi, Vietnam.
Binh Hoa NguyenNational Lung Hospital, Hanoi, Vietnam.
Thi Thanh Thuy HoangNational Lung Hospital, Hanoi, Vietnam.
Phuong Chi NguyenThe Woolcock Institute of Medical Research, Hanoi, Vietnam.
Kavindhran VelenThe Central Clinical School, Faculty of Medicine and Health, The University of Sydney, 90-92 Parramatta Road, Sydney, NSW, 2006, Australia.
Guy Barrington MarksThe Woolcock Institute of Medical Research, Sydney, NSW, 2037, Australia.
Greg James FoxThe Central Clinical School, Faculty of Medicine and Health, The University of Sydney, 90-92 Parramatta Road, Sydney, NSW, 2006, Australia.

Funding

National Health and Medical Research Council APP1148372
6 · The paper itself

Abstract

backgroundImproving treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) is a leading priority for global TB control. This retrospective cohort study evaluated the factors associated with treatment success among patients treated for MDR-TB in two provinces in Vietnam.

methodsTreatment outcomes were evaluated for adult patients treated in Hanoi and Thanh Hoa provinces between 2014 and 2016. The primary outcome was the proportion of patients with treatment success, defined as cure or treatment completion. Logistic regression analysis was used to evaluate the relationship between patient clinical and microbiological characteristics and treatment success.

resultsTreatment outcomes were reported in 612 of 662 patients; of these, 401 (65.5)% were successfully treated. The odds of treatment success were lower for male patients (aOR 0.56, 95% CI 0.34-0.90), for people living with HIV (aOR 0.44, 95% CI 0.20-1.00), and for patients treated for extensive antibiotic resistance (pre-XDR-/XDT-TB) (aOR 0.53, 95% CI 0.29-0.97), compared with others. Patients who achieved culture conversion in the first 4 months of treatment had increased odds (aOR 2.93, 95% CI 1.33-6.45) of treatment success. In addition, loss to follow-up was less common among patients covered by social health insurance compared to those who paid for treatment out-of-pocket (aOR 0.55, 95% CI 0.32-0.95).

conclusionsAmong patients with MDR-TB, males, people living with HIV, and those with more extensive antibiotic resistance at diagnosis are at greatest risk of an unsuccessful treatment outcome. Efforts to optimise the management of co-morbidities (such as HIV), ensure rapid bacteriological conversion, and provide financial support for patients promise to improve treatment outcomes.

Indexed as

Antitubercular AgentsTuberculosis, Multidrug-ResistantAdultHumansMaleRetrospective StudiesTreatment OutcomeVietnamAntitubercular AgentsBacteriological conversionCo-morbiditiesGenderHIVMDR-TB

Identifiers

PMID35057754
PMCPMC8772201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.