Evidence map›Paper›PMID 35057535›Full record

SynthesisNutrients2022

Efficacy of Probiotics in Rheumatoid Arthritis and Spondyloarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Pauline Sanchez, Jean-Guillaume Letarouilly, Yann Nguyen, Johanna Sigaux, Thomas Barnetche, Sébastien Czernichow, René-Marc Flipo, Jérémie Sellam, Claire Daïen

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Anti-Inflammatory Potential ofMicroorganisms · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.International journal of molecular sciences · 2026
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Pauline SanchezDepartment of Rheumatology, CHU de Montpellier, Montpellier University, F-34295 Montpellier, France.
Jean-Guillaume LetarouillyDepartment of Rheumatology, CHU Lille, Université de Lille, F-59000 Lille, France.ORCID 0000-0003-2793-6303
Yann NguyenDepartment of Internal Medicine, Hôpital Beaujon, AP-HP Nord, Université de Paris, F-92100 Clichy, France.ORCID 0000-0002-0866-3824
Johanna SigauxDepartment of Rheumatology, Hôpital Avicenne, AP-HP, INSERM U1125, Université Paris 13, F-93017 Bobigny, France.
Thomas BarnetcheDepartment of Rheumatology, FHU ACRONIM, Bordeaux University Hospital, F-33076 Bordeaux, France.
Sébastien CzernichowDepartment of Nutrition, Specialized Obesity Center, Hôpital Européen Georges Pompidou, Université de Paris, AP-HP, F-75015 Paris, France.
René-Marc FlipoDepartment of Rheumatology, CHU Lille, Université de Lille, F-59000 Lille, France.
Jérémie SellamDepartment of Rheumatology, Hôpital Saint Antoine, AP-HP, DMU 3ID, CRSA Inserm UMRS_938, Sorbonne Université, F-75012 Paris, France.
Claire DaïenDepartment of Rheumatology, CHU de Montpellier, Montpellier University, F-34295 Montpellier, France.
Inserm · FRUniversité de Lille · FRCentre National de la Recherche Scientifique · FRHôpital Beaujon · FRUniversité de Bordeaux · FRUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to provide a systematic review and meta-analysis of randomized controlled trials assessing the effect of probiotics supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis (SpA), or psoriatic arthritis).

methodsA systematic literature review and meta-analysis from RA and SpA randomized controlled trials were conducted searching for articles in MEDLINE/PubMed and abstracts from recent international rheumatology meetings. The control group was a placebo or another dietary intervention. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration tool and the Jadad scale.

resultsThe initial search yielded 173 articles. Of these, 13 studies were included in the qualitative synthesis, 8 concerning a total of 344 RA patients and 2 concerning a total of 197 SpA patients. Three meta-analyses were also analyzed. Probiotic strains and quantities used were different among trials (5 studies using

conclusionsProbiotic supplementation might decrease RA activity with a moderate decrease effect on CRP, but lack of evidence and studies' heterogeneity do not allow us to propose them to patients with inflammatory arthritis to control their disease. Further RCTs are required in the future to determinate the efficacy of probiotics and the optimal administration design.

Indexed as

AdultArthritis, RheumatoidFemaleHumansMaleMiddle AgedProbioticsRandomized Controlled Trials as TopicSpondylarthritisTreatment Outcomedisease activitymicrobiotaprobioticsrheumatoid arthritisspondyloarthritis

Identifiers

PMID35057535
PMCPMC8779560
OpenAlexW4206423356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.