Evidence map›Paper›PMID 35057532›Full record

ArticleNutrients2022

Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects.

Carlo De Matteis, Lucilla Crudele, Marica Cariello, Stefano Battaglia, Giuseppina Piazzolla, Patrizia Suppressa, Carlo Sabbà, Elena Piccinin, Antonio Moschetta

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Carlo De MatteisDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-6628-2184
Lucilla CrudeleDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0541-6211
Marica CarielloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Stefano BattagliaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-6258-4847
Giuseppina PiazzollaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Patrizia SuppressaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Carlo SabbàDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Elena PiccininDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6514-2689
Antonio MoschettaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-2123-6074
University of Bari Aldo Moro · ITIstituto Nazionale Biostrutture e Biosistemi · IT

Funding

EU-JPI HDL-INTIMIC -MIUR FatmalMinistry of Education, Universities and Research PON AIM1853334 - Attività 2, linea 1Ministry of Education, Universities and Research PON "R&I" 2014-2020 "BIOMIS" cod.ARS01_01220Ministry of Education, Universities and Research PRIN 2017 Cod. 2017 J3E2W2POR Puglia FESR FSE 2014-2020, "INNOMA" cod. 4TCJLV4
6 · The paper itself

Abstract

Vitamin D deficiency is often linked with Metabolic Syndrome, both being more frequent with ageing and associated with an increase inflammatory state. Recently, monocytes-to-high density lipoprotein (HDL) ratio (MHR) has emerged as a powerful index to predict systemic inflammation. In this cross-sectional study, we investigated the association between circulating vitamin D level (25-OH vitamin D) and inflammatory status in a population of 1048 adult individuals. Our study reveals an inverse association between 25-OH vitamin D levels and MHR in the overall population. When the population is stratified by gender, waist circumference, and body mass index (BMI), we observed that while in men this relation is strongly significative only in condition of central obesity, in women a lifelong negative correlation exists between circulating 25-OH vitamin D and MHR and it is independent of the metabolic status. These observations underscore the relevance of circulating biomarkers such as MHR in the prediction of systemic inflammatory conditions sustained by vitamin D deficiency also in healthy and young women.

Indexed as

AdultBiomarkersBody Mass IndexCross-Sectional StudiesFemaleHumansLeukocyte CountLipoproteins, HDLMaleMetabolic SyndromeMiddle AgedMonocytesPredictive Value of TestsSex FactorsVitamin DVitamin D Deficiency25-hydroxyvitamin DBiomarkersLipoproteins, HDLVitamin Dgender differencemetabolic syndromeMHR indexvitamin D

Identifiers

PMID35057532
PMCPMC8778051
OpenAlexW4205283577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.