Evidence map›Paper›PMID 35057491›Full record

ArticleNutrients2022

The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis.

Kevin J Scully, Laura T Jay, Steven Freedman, Gregory S Sawicki, Ahmet Uluer, Joel S Finkelstein, Melissa S Putman

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05723445 (The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05723445 narecruitingnot on this mapstarted 2023, after this paper: background citation

The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

TypeinterventionalSponsorRhode Island HospitalRan2023 to 2026Enrolled15ConditionsCystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis With Intestinal ManifestationsArmsLow Glycemic Load Diet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Guideline
  3. Interrelationships among handgrip strength, body composition, physical activity, and quality of life in adults with cystic fibrosis: A cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Observational
  4. Article
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kevin J ScullyDivision of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-7886-9871
Laura T JayDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Steven FreedmanHarvard Medical School, Boston, MA 02115, USA.
Gregory S SawickiHarvard Medical School, Boston, MA 02115, USA.
Ahmet UluerHarvard Medical School, Boston, MA 02115, USA.
Joel S FinkelsteinHarvard Medical School, Boston, MA 02115, USA.
Melissa S PutmanHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7655-8954
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Research in Development Endocrinology and MetabolismT32DK007699 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI JOEL N HIRSCHHORN · 1992 to 2026
$7.1M
The Endocrine Complications of Cystic Fibrosis: the Role of CFTRK23DK102600 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI PUTMAN, MELISSA SUSAN · 2015 to 2018
$634k
NCATS NIH HHS UL1 TR001102NIDDK NIH HHS K23DK102600NIDDK NIH HHS T32 DK007699NIH HHS 1UL1 TR001102Vertex Pharmaceuticals (United States) Vertex Investigator Initiated Studies Grant
6 · The paper itself

Abstract

Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis (CF) than body mass index (BMI). Little is known about how diet quality and exercise may impact body composition in these patients. Dual X-ray absorptiometry (DXA) body composition, 24-h dietary recall, and physical activity were assessed in a cross-sectional analysis of 38 adolescents and adults with CF and 19 age-, race-, and gender-matched healthy volunteers. Compared with the healthy volunteers, participants with CF had a lower appendicular lean mass index (ALMI), despite no observed difference in BMI, and their diets consisted of higher glycemic index foods with a greater proportion of calories from fat and a lower proportion of calories from protein. In participants with CF, pulmonary function positively correlated with measures of lean mass, particularly ALMI, and negatively correlated with multiple measures of body fat after controlling for age, gender, and BMI. Higher physical activity levels were associated with greater ALMI and lower body fat. In conclusion, body composition measures, particularly ALMI, may better predict key clinical outcomes in individuals with CF than BMI. Future longitudinal studies analyzing the effect of dietary intake and exercise on body composition and CF-specific clinical outcomes are needed.

Indexed as

Absorptiometry, PhotonAdipose TissueAdolescentAdultBody CompositionBody Mass IndexCase-Control StudiesCross-Sectional StudiesCystic FibrosisDiet SurveysEatingExerciseFemaleHumansLungMaleappendicular lean mass indexbody compositioncystic fibrosisdietary intakedual-energy X-ray absorptiometryfat mass indexlean body mass

Identifiers

PMID35057491
PMCPMC8777582
OpenAlexW4205808809

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.