Evidence map›Paper›PMID 35057487›Full record

ArticleNutrients2022

An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles.

Sónia Rocha, Natália Aniceto, Rita C Guedes, Hélio M T Albuquerque, Vera L M Silva, Artur M S Silva, Maria Luísa Corvo, Eduarda Fernandes, Marisa Freitas

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sónia RochaLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-7786-2731
Natália AnicetoResearch Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Rita C GuedesResearch Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.ORCID 0000-0002-5790-9181
Hélio M T AlbuquerqueLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-5905-3316
Vera L M SilvaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-0938-5085
Artur M S SilvaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-2861-8286
Maria Luísa CorvoResearch Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.ORCID 0000-0002-6332-3937
Eduarda FernandesLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-6424-0976
Marisa FreitasLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-9114-9967
Rede de Química e Tecnologia · PTUniversidade do Porto · PTUniversity of Lisbon · PT

Funding

Fundação para a Ciência e Tecnologia 2020.04126.CEECIND/CP1596/CT0006Fundação para a Ciência e Tecnologia CEECINST/00026/2018Fundação para a Ciência e Tecnologia PD/BD/145169/2019Fundação para a Ciência e Tecnologia POCI-01-0145-FEDER-029241Fundação para a Ciência e Tecnologia PTDC/MED-QUI/29241/2017Fundação para a Ciência e Tecnologia UIDB/50006/2020Fundação para a Ciência e Tecnologia UID/DTP/04138/2020Fundação para a Ciência e Tecnologia UIDP/04138/2020
6 · The paper itself

Abstract

Glycogen phosphorylase (GP) is a key enzyme in the glycogenolysis pathway. GP inhibitors are currently under investigation as a new liver-targeted approach to managing type 2 diabetes

Indexed as

ChromonesDiabetes Mellitus, Type 2FlavonoidsGlycogen PhosphorylaseHumansHypoglycemic AgentsMolecular Docking SimulationPyrazolesStructure-Activity Relationship2-styrylchromoneChromonesFlavonoidsGlycogen PhosphorylaseHypoglycemic AgentsPyrazolesglycogen phosphorylasenatural compoundsstructure–activity relationshipsynthetic compoundstype 2 diabetes

Identifiers

PMID35057487
PMCPMC8781192
OpenAlexW4205300127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.