Evidence map›Paper›PMID 35057189›Full record

ArticleMaterials (Basel, Switzerland)2022

A Two-Step Approach to Tune the Micro and Nanoscale Morphology of Porous Niobium Oxide to Promote Osteointegration.

Paolo Canepa, Giuseppe Firpo, Elena Gatta, Roberto Spotorno, Paolo Giannoni, Rodolfo Quarto, Maurizio Canepa, Ornella Cavalleri

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Paolo CanepaDipartimento di Fisica and OPTMATLAB, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.ORCID 0000-0002-2205-286X
Giuseppe FirpoDipartimento di Fisica and NANOMED, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.
Elena GattaDipartimento di Fisica, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.
Roberto SpotornoDipartimento di Chimica e Chimica Industriale, Università di Genova, Via Dodecaneso 31, 16146 Genova, Italy.ORCID 0000-0003-3593-0454
Paolo GiannoniDipartimento di Medicina Sperimentale, Università di Genova, Via Leon Battista Alberti 2, 16132 Genova, Italy.ORCID 0000-0002-7206-376X
Rodolfo QuartoDipartimento di Medicina Sperimentale, Università di Genova, Via Leon Battista Alberti 2, 16132 Genova, Italy.ORCID 0000-0002-1146-894X
Maurizio CanepaDipartimento di Fisica and OPTMATLAB, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.ORCID 0000-0002-5148-1233
Ornella CavalleriDipartimento di Fisica and OPTMATLAB, Università di Genova, Via Dodecaneso 33, 16146 Genova, Italy.ORCID 0000-0002-3473-2424
University of Genoa · ITIstituto Nazionale di Fisica Nucleare, Sezione di Genova · ITOspedale Policlinico San Martino · IT

Funding

Fondo Sociale Europeo Regione Liguria DPU12UNIGE82/3600Ministry of Education, Universities and Research Department of Excellence 2018 - 2022
6 · The paper itself

Abstract

We present a two-step surface modification process to tailor the micro and nano morphology of niobium oxide layers. Niobium was firstly anodized in spark regime in a Ca- and P-containing solution and subsequently treated by acid etching. The effects of anodizing time and applied potential on the surface morphology is investigated with SEM and AFM, complemented by XPS compositional analysis. Anodizing with a limiting potential of 250 V results in the fast growth of oxide layers with a homogeneous distribution of micro-sized pores. Cracks are, however, observed on 250 V grown layers. Limiting the anodizing potential to 200 V slows down the oxide growth, increasing the anodizing time needed to achieve a uniform pore coverage but produces fracture-free oxide layers. The surface nano morphology is further tuned by a subsequent acid etching process that leads to the formation of nano-sized pits on the anodically grown oxide surface. In vitro tests show that the etching-induced nanostructure effectively promotes cell adhesion and spreading onto the niobium oxide surface.

Indexed as

AFMASDCa/PetchingniobiumosteoblastSEMXPS

Identifiers

PMID35057189
PMCPMC8778385
OpenAlexW4205196329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.