Evidence map›Paper›PMID 35057075›Full record

ArticlePharmaceutics2022

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development.

Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Claudia MirandaUnit of Modeling & Experimental Biopharmaceutics, Central "Marta Abreu" de Las Villas, Centro de Bioactivos Químicos Universidad, Santa Clara 50100, Cuba.
Alejandro Ruiz-PicazoDepartment Engineering of Pharmacokinetics and Pharmaceutical Technology Area, Miguel Hernandez University, 03550 Alicante, Spain.ORCID 0000-0003-1281-8208
Paula PomaresDepartment Engineering of Pharmacokinetics and Pharmaceutical Technology Area, Miguel Hernandez University, 03550 Alicante, Spain.
Isabel Gonzalez-AlvarezDepartment Engineering of Pharmacokinetics and Pharmaceutical Technology Area, Miguel Hernandez University, 03550 Alicante, Spain.ORCID 0000-0002-1685-142X
Marival BermejoDepartment Engineering of Pharmacokinetics and Pharmaceutical Technology Area, Miguel Hernandez University, 03550 Alicante, Spain.ORCID 0000-0001-5022-0544
Marta Gonzalez-AlvarezDepartment Engineering of Pharmacokinetics and Pharmaceutical Technology Area, Miguel Hernandez University, 03550 Alicante, Spain.ORCID 0000-0002-8122-1504
Alex AvdeefIn-ADME Research, 1732 First Avenue # 102, New York, NY 10128, USA.
Miguel-Ángel Cabrera-PérezUnit of Modeling & Experimental Biopharmaceutics, Central "Marta Abreu" de Las Villas, Centro de Bioactivos Químicos Universidad, Santa Clara 50100, Cuba.ORCID 0000-0001-5897-2230
Universitat de Miguel Hernández d'Elx · ES

Funding

Agencia Estatal Investigación SAF2016-78756(AEI/FEDER, EU
6 · The paper itself

Abstract

The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the p

Indexed as

BCSCaco-2intestinal permeabilityJM-20MDCKpKasolubility-pH

Identifiers

PMID35057075
PMCPMC8780741
OpenAlexW4205913290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.