Evidence map›Paper›PMID 35057052›Full record

ArticlePharmaceutics2022

Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure.

Jitendra Shrestha, Seong Woong Kim, Su-Bin Kim, Yoon Sin Oh, Sung Hwan Ki, Taeho Lee, Sang-Bum Kim, Taeuk Park, Dong Jae Baek, Eun-Young Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jitendra ShresthaCollege of Pharmacy, Mokpo National University, Muan-gun 58554, Korea.ORCID 0000-0002-5344-994X
Seong Woong KimCollege of Pharmacy, Mokpo National University, Muan-gun 58554, Korea.
Su-Bin KimCollege of Pharmacy, Mokpo National University, Muan-gun 58554, Korea.
Yoon Sin OhDepartment of Food and Nutrition, Eulji University, Seongnam 13135, Korea.ORCID 0000-0003-3995-4429
Sung Hwan KiCollege of Pharmacy, Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-0761-3750
Taeho LeeCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea.
Sang-Bum KimNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
Taeuk ParkLaboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
Dong Jae BaekCollege of Pharmacy, Mokpo National University, Muan-gun 58554, Korea.ORCID 0000-0001-6100-488X
Eun-Young ParkCollege of Pharmacy, Mokpo National University, Muan-gun 58554, Korea.
Mokpo National University · KRChosun University · KRDaegu-Gyeongbuk Medical Innovation Foundation · KREulji University · KRKyungpook National University · KR

Funding

National Research Foundation of Korea 2020R1A2C1012156, 2020R1F1A1068316
6 · The paper itself

Abstract

Sphingosine kinase (SK) enzyme, a central player of sphingolipid rheostat, catalyzes the phosphorylation of sphingosine to the bioactive lipid mediator sphingosine 1 phosphate (S1P), which regulates cancer cell proliferation, migration, differentiation, and angiogenesis through its extracellular five G protein-coupled S1P receptors (S1PR

Indexed as

anticancer agentcolorectal cancerderivativePP2AS1PSK inhibitor

Identifiers

PMID35057052
PMCPMC8779255
OpenAlexW4205476911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.