Evidence map›Paper›PMID 35056994›Full record

ArticlePharmaceutics2022

SonoVue

Spiros Kotopoulis, Mihaela Popa, Mireia Mayoral Safont, Elisa Murvold, Ragnhild Haugse, Anika Langer, Georg Dimcevski, Christina Lam, Tormod Bjånes, Odd Helge Gilja and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The Role of Molecular Imaging in Personalized Medicine.Journal of personalized medicine · 2023
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Spiros KotopoulisNational Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.
Mihaela PopaKinN Therapeutics AS, Jonas Lies vei 65, 5021 Bergen, Norway.
Mireia Mayoral SafontKinN Therapeutics AS, Jonas Lies vei 65, 5021 Bergen, Norway.
Elisa MurvoldNational Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.
Ragnhild HaugseCentre for Pharmacy, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.ORCID 0000-0001-8793-3097
Anika LangerCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.
Georg DimcevskiDepartment of Clinical Medicine, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.
Christina LamCentre for Pharmacy, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.ORCID 0000-0003-0569-2491
Tormod BjånesDepartment of Medical Biochemistry and Pharmacology, Section of Clinical Pharmacology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.ORCID 0000-0002-0221-7807
Odd Helge GiljaNational Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.
Emmet Mc CormackCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.ORCID 0000-0002-7621-4625
University of Bergen · NOHaukeland University Hospital · NO

Funding

National Institute of Health R01CA199646Norwegian Cancer Society 6833652, 182735The Research Council of Norway 250317, 223250, 262652Western Norway Regional Health Authority 911779, 911182, 912035 and 912146
6 · The paper itself

Abstract

The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has shown great promise in cancer therapy from in vitro to ongoing clinical studies. The fastest bench-to-bedside translation involves the use of ultrasound contrast agents (microbubbles) and clinical diagnostic scanners. Despite substantial research in this field, it is currently not known which of these microbubbles result in the greatest enhancement of therapy within the applied conditions. Three microbubble formulations-SonoVue

Indexed as

microbubblespancreatic cancersonoporationtargeted drug deliveryultrasoundultrasound-enhanced therapy

Identifiers

PMID35056994
PMCPMC8777813
OpenAlexW4206566668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.