Evidence map›Paper›PMID 35056982›Full record

ArticlePharmaceutics2021

Inhalable, Spray-Dried Terbinafine Microparticles for Management of Pulmonary Fungal Infections: Optimization of the Excipient Composition and Selection of an Inhalation Device.

Khaled Almansour, Iman M Alfagih, Alhassan H Aodah, Fawaz Alheibshy, Raisuddin Ali, Turki Al Hagbani, Mustafa M A Elsayed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Khaled AlmansourDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail 55473, Saudi Arabia.ORCID 0000-0003-1913-9005
Iman M AlfagihDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 12372, Saudi Arabia.ORCID 0000-0002-1313-1283
Alhassan H AodahNational Center of Biotechnology, Life Science & Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.ORCID 0000-0001-5947-986X
Fawaz AlheibshyDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail 55473, Saudi Arabia.
Raisuddin AliDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 12372, Saudi Arabia.ORCID 0000-0001-9892-2158
Turki Al HagbaniDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail 55473, Saudi Arabia.
Mustafa M A ElsayedDepartment of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail 55473, Saudi Arabia.ORCID 0000-0001-5779-8170
University of Ha'il · SAKing Saud University · SAKing Abdulaziz City for Science and Technology · SA

Funding

Scientific Research Deanship, University of Ha'il, Saudi Arabia RG-20 131
6 · The paper itself

Abstract

Terbinafine is a broad-spectrum antifungal agent with therapeutic potential against pulmonary aspergillosis. The main aim of the current study was to investigate the potential of l-leucine, alone and in combination with mannitol, to improve the performance of spray-dried terbinafine microparticles for inhalation. The study also aimed to investigate the potential of the low resistance Cyclohaler

Indexed as

Cyclohaler®dry powder inhalationHandihaler®leucinemannitolnano spray dryingpulmonary aspergillosisterbinafine

Identifiers

PMID35056982
PMCPMC8781528
OpenAlexW4206659927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.