Evidence map›Paper›PMID 35056938›Full record

ArticlePharmaceutics2021

"Smart" Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy.

Ekaterina A Mordovina, Valentina O Plastun, Arkady S Abdurashitov, Pavel I Proshin, Svetlana V Raikova, Daniil N Bratashov, Olga A Inozemtseva, Irina Yu Goryacheva, Gleb B Sukhorukov, Olga A Sindeeva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ekaterina A MordovinaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0003-1773-9015
Valentina O PlastunScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.
Arkady S AbdurashitovCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia.
Pavel I ProshinCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia.
Svetlana V RaikovaSaratov Hygiene Medical Research Center of the FBSI «FSC Medical and Preventive Health Risk Management Technologies», 1A Zarechnaya Str., 410022 Saratov, Russia.
Daniil N BratashovScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0002-2096-4478
Olga A InozemtsevaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.
Irina Yu GoryachevaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0003-1781-6180
Gleb B SukhorukovCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia.ORCID 0000-0001-6213-0562
Olga A SindeevaCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia.ORCID 0000-0002-5288-4157
Saratov State University · RUSkolkovo Institute of Science and Technology · RUSaratov State Medical University · RU

Funding

Grant of the President of the Russian Federation МК-4273.2021.1.4Russian Federation Grant 14.Z50.31.0044
6 · The paper itself

Abstract

Bacterial infections are a severe medical problem, especially in traumatology, orthopedics, and surgery. The local use of antibiotics-elution materials has made it possible to increase the effectiveness of acute infections treatment. However, the infection prevention problem remains unresolved. Here, we demonstrate the fabrication of polylactic acid (PLA) "smart" films with microchamber arrays. These microchambers contain ceftriaxone as a payload in concentrations ranging from 12 ± 1 μg/cm

Indexed as

antibioticsbacterial infectionsbacteriological activityceftriaxonedrug deliverymicrochamber arraysPLAprolonged releaseStaphylococcus aureusultrasound-induced release

Identifiers

PMID35056938
PMCPMC8781070
OpenAlexW4200157347

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.