Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 1 institution in 1 country.
Niccolò ChiaramonteSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0003-1029-2118
Alessio GabelliniSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0001-9529-7107
Andrea AngeliSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0002-1470-7192
Gianluca BartolucciSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0002-5631-8769
Laura BraconiSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Silvia DeiSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0003-0898-7148
Elisabetta TeodoriSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0002-9705-3875
Claudiu T SupuranSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
Maria Novella RomanelliSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0002-5685-3403
University of Florence · IT
Funding
the Italian Ministry of University and Research grant PRIN rot. 2017XYBP2RUniversity of Florence RICATEN20
6 · The paper itself
Abstract
A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (K
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators. · full record | OpenQuestion