Evidence map›Paper›PMID 35056800›Full record

ArticleMolecules (Basel, Switzerland)2022

A New Series of Indeno[1,2-

Ahmet Özdemir, Halilibrahim Ciftci, Belgin Sever, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Mehlika Dilek Altıntop

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ahmet ÖzdemirDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.ORCID 0000-0003-0280-5550
Halilibrahim CiftciDepartment of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.ORCID 0000-0002-9796-7669
Belgin SeverDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.ORCID 0000-0003-4847-9711
Hiroshi TateishiMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.ORCID 0000-0003-1225-0720
Masami OtsukaDepartment of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.
Mikako FujitaMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Mehlika Dilek AltıntopDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.ORCID 0000-0002-8159-663X
Anadolu University · TRKumamoto University · JPKoç University · TR

Funding

Anadolu University 2105S095Anadolu University 2107S101
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death throughout the world. Due to the shortcomings of traditional chemotherapy, targeted therapies have come into prominence for the management of NSCLC. In particular, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy has emerged as a first-line therapy for NSCLC patients with EGFR-activating mutations. In this context, new indenopyrazoles, which were prepared by an efficient microwave-assisted method, were subjected to in silico and in vitro assays to evaluate their potency as EGFR TK-targeted anti-NSCLC agents. Compound

Indexed as

Antineoplastic AgentsApoptosisCarcinoma, Non-Small-Cell LungCell Line, TumorComputer SimulationErbB ReceptorsErlotinib HydrochlorideHumansLeukocytes, MononuclearLung NeoplasmsProtein Kinase InhibitorsProtein-Tyrosine KinasesPyrazolesAntineoplastic AgentsEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideProtein Kinase InhibitorsProtein-Tyrosine KinasesPyrazolesanticancer activityapoptosisepidermal growth factor receptorindenopyrazolesmicrowave-assisted synthesisnon-small cell lung cancertyrosine kinases

Identifiers

PMID35056800
PMCPMC8778314
OpenAlexW4206485501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.