Evidence map›Paper›PMID 35056795›Full record

ArticleMolecules (Basel, Switzerland)2022

Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.

Wei-Chieh Huang, Shaw-Min Hou, Ming-Ping Wu, Chih-Wei Hsia, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Periyakali Saravana Bhavan, Chi-Li Chung, Joen-Rong Sheu

Open access · goldAbstract readComparative Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Wei-Chieh HuangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Shaw-Min HouGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Ming-Ping WuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chih-Wei HsiaGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-4508-6181
Thanasekaran JayakumarGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chih-Hsuan HsiaTranslational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.
Periyakali Saravana BhavanDepartment of Zoology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.ORCID 0000-0003-2056-4607
Chi-Li ChungDepartment of Internal Medicine, Division of Pulmonary Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0003-0656-976X
Joen-Rong SheuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-8265-3678
Taipei Medical University · TWBharathiar University · INChi Mei Medical Center · TWFu Jen Catholic University · TWTaipei Medical University Hospital · TW

Funding

Cathay General Hospital CGH-MR-A10928Chi Mei Medical Center-Taipei Medical University 108CM-TMU-08Ministry of Science and Technology of Taiwan MOST 107-2320-B-038-035-MY2Ministry of Science and Technology of Taiwan MOST 108-2320-B-038-031-MY3Taipei Medical University DP2-107-21121-N-02
6 · The paper itself

Abstract

Platelets play a critical role in arterial thrombosis. Rutaecarpine (RUT) was purified from

Indexed as

AnimalsDisease Models, AnimalFibrinolytic AgentsFree RadicalsFree Radical ScavengersHumansI-kappa B KinaseImidazolesIndole AlkaloidsMaleMiceMice, Inbred ICRNF-kappa BNitrilesp38 Mitogen-Activated Protein KinasesPlatelet Activation3-(4-methylphenylsulfonyl)-2-propenenitrileFibrinolytic AgentsFree RadicalsFree Radical ScavengersI-kappa B KinaseImidazolesIndole AlkaloidsNF-kappa BNitrilesp38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsP-SelectinPyridinesQuinazolinesQuinazolinonesrutecarpineSB 203580SulfonesTranscription Factor RelADPPHhuman plateletsNF-κBp38 MAPKpulmonary thrombosisrutaecarpine

Identifiers

PMID35056795
PMCPMC8780806
OpenAlexW4205919897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.