Evidence map›Paper›PMID 35056769›Full record

ArticleMolecules (Basel, Switzerland)2022

Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis.

Hyoung Moon Kim, Seyeon Oh, Kyung-A Byun, Jin Young Yang, Hye Jin Sun, Donghwan Kang, Kuk Hui Son, Kyunghee Byun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hyoung Moon KimDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea.ORCID 0000-0001-9068-5813
Seyeon OhFunctional Cellular Networks Laboratory, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Korea.
Kyung-A ByunDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea.
Jin Young YangFunctional Cellular Networks Laboratory, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Korea.
Hye Jin SunJeisys Medical Inc., Seoul 08501, Korea.
Donghwan KangJeisys Medical Inc., Seoul 08501, Korea.
Kuk Hui SonDepartment of Thoracic and Cardiovascular Surgery, Gil Medical Center, Gachon University, Incheon 21565, Korea.
Kyunghee ByunDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea.
Gachon University · KRGachon University Gil Medical Center · KR

Funding

Jeisys Medical Inc 2020-5004
6 · The paper itself

Abstract

Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphangiogenesis by activating the BRAF/MEK/ERK pathway and decreasing tyrosinase activity, in the UV-B exposed animal model. The HSP90/BRAF/MEK/ERK pathway was upregulated by RF. Tyrosinase activity and the VEGF-C/VEGFR 3/PI3K/pAKT1/2/pERK1/2 pathway, which increase lymphangiogenesis, as well as the expression of the lymphatic endothelial marker LYVE-1, were increased by RF. Additionally, the number of melanin-containing dermal macrophages, the melanin content in the lymph nodes, and melanin deposition in the skin were decreased by RF. In conclusion, RF increased HSP90/BRAF/MEK/ERK expression, which decreased tyrosinase activity and increased lymphangiogenesis to eventually promote the clearance of dermal melanin-containing macrophages, thereby decreasing skin pigmentation.

Indexed as

Radio WavesUltraviolet RaysBiomarkersExtracellular Signal-Regulated MAP KinasesHSP90 Heat-Shock ProteinsHyperpigmentationImmunohistochemistryLymphangiogenesisMacrophagesMelaninsModels, BiologicalProto-Oncogene Proteins B-rafSignal TransductionSkin PigmentationVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3BiomarkersBRAF protein, humanExtracellular Signal-Regulated MAP KinasesHSP90 Heat-Shock ProteinsMelaninsProto-Oncogene Proteins B-rafVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3dermal macrophage-containing melaninlymphangiogenesisradiofrequency microneedlingskin pigmentationultraviolet-B

Identifiers

PMID35056769
PMCPMC8780734
OpenAlexW4206378820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.