Evidence map›Paper›PMID 35056762›Full record

ArticleMolecules (Basel, Switzerland)2022

New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity.

Christos Vassileiou, Stefania Kalantzi, Eleanna Vachlioti, Constantinos M Athanassopoulos, Christos Koutsakis, Zoi Piperigkou, Nikos Karamanos, Theodora Stivarou, Peggy Lymberi, Konstantinos Avgoustakis and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Polyamine-Drug Conjugates: Do They Boost Drug Activity?Molecules (Basel, Switzerland) · 2023
    Review
  3. Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Christos VassileiouLaboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.
Stefania KalantziLaboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.
Eleanna VachliotiLaboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.
Constantinos M AthanassopoulosLaboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.ORCID 0000-0002-7549-1911
Christos KoutsakisBiochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.ORCID 0000-0001-8705-7867
Zoi PiperigkouBiochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.ORCID 0000-0002-0472-5389
Nikos KaramanosBiochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.ORCID 0000-0003-3618-0288
Theodora StivarouImmunology Laboratory, Department of Immunology, Hellenic Pasteur Institute, 127 Vas. Sofias Avenue, Ampelokipi, 115 21 Athens, Greece.ORCID 0000-0002-3743-844X
Peggy LymberiImmunology Laboratory, Department of Immunology, Hellenic Pasteur Institute, 127 Vas. Sofias Avenue, Ampelokipi, 115 21 Athens, Greece.
Konstantinos AvgoustakisDepartment of Pharmacy, University of Patras, 265 04 Patras, Greece.
Dionissios PapaioannouLaboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 265 04 Patras, Greece.ORCID 0000-0001-5845-4134
University of Patras · GRPasteur Hellenic Institute · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs

Indexed as

AnimalsAntineoplastic AgentsCell ProliferationDrug Screening Assays, AntitumorHeterocyclic CompoundsHumansIndolesMCF-7 CellsMolecular StructurePolyaminesSpidersSpider VenomsStructure-Activity RelationshipWaspsAntineoplastic Agentsdelta-philanthotoxinHeterocyclic CompoundsHO 416bIndolesJSTX-3PolyaminesSpider Venoms4-(3-trifluoromethyldiazirin-3-yl)benzoic acidantiproliferative activitybreast cancer cellscytotoxicityhydroxy amino acids(indol-3-yl)acetic acidlipophilic head groupspolyaminespolyamine toxinspropargylglycine

Identifiers

PMID35056762
PMCPMC8777946
OpenAlexW4205906110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.