Evidence map›Paper›PMID 35056761›Full record

ArticleMolecules (Basel, Switzerland)2022

The Untargeted Phytochemical Profile of Three Meliaceae Species Related to In Vitro Cytotoxicity and Anti-Virulence Activity against MRSA Isolates.

Leilei Zhang, Maha M Ismail, Gabriele Rocchetti, Nesrin M Fayek, Luigi Lucini, Fatema R Saber

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Biofilm · 2024
    Review
  6. Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Leilei ZhangDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.ORCID 0000-0002-9278-0459
Maha M IsmailMicrobiology and Immunology Department, Faculty of Pharmacy, Cairo University, Kasr el Aini St., Cairo 11562, Egypt.ORCID 0000-0002-8988-2702
Gabriele RocchettiDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.ORCID 0000-0003-3488-4513
Nesrin M FayekPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini st., Cairo 11562, Egypt.ORCID 0000-0001-5932-6257
Luigi LuciniDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.ORCID 0000-0002-5133-9464
Fatema R SaberPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini st., Cairo 11562, Egypt.ORCID 0000-0002-5968-1141
Cairo University · EGUniversità Cattolica del Sacro Cuore · IT

Funding

Faculty of pharmacy, Cairo University IRG project 2019-2021
6 · The paper itself

Abstract

backgroundA high mortality rate is associated with about 80% of all infections worldwide, mainly due to antimicrobial resistance. Various antimicrobial and cytotoxic activities have been proposed for Meliaceae species. This study aimed to evaluate the in vitro anti-virulence and cytotoxic effect of the leaf extracts of MATERIAL AND

methodsWe explored three plants of this family against a panel of Methicillin-resistant

resultsA total of 279 compounds were putatively annotated to include different phytochemical classes, such as flavonoids (108), limonoids/terpenoids (59), phenolic acids (49) and lower-molecular-weight phenolics (39).

conclusionThese findings suggested that both

Indexed as

Anti-Bacterial AgentsAntineoplastic Agents, PhytogenicBiofilmsCell Line, TumorChromatography, High Pressure LiquidHumansMass SpectrometryMeliaceaeMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMultivariate AnalysisPhytochemicalsPlant ExtractsPlant LeavesVirulenceAnti-Bacterial AgentsAntineoplastic Agents, PhytogenicPhytochemicalsPlant ExtractsbiofilmcytotoxicityMDRMeliaceaemetabolomic profilingMRSAstaphyloxanthin

Identifiers

PMID35056761
PMCPMC8777635
OpenAlexW4206227767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.