Evidence map›Paper›PMID 35056668›Full record

ArticleMolecules (Basel, Switzerland)2022

Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives.

Nasima Arshad, Muhammad Ismail Mir, Fouzia Perveen, Aneela Javed, Memona Javaid, Aamer Saeed, Pervaiz Ali Channar, Shahid Iqbal Farooqi, Saad Alkahtani, Jamshed Anwar

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Synthesis of azole-linkedNanoscale advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nasima ArshadDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.ORCID 0000-0002-4257-9909
Muhammad Ismail MirDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.ORCID 0000-0002-9799-6291
Fouzia PerveenResearch Center for Modeling and Simulations, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Aneela JavedHealthcare Biotechnology Atta-ur-Rehman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.ORCID 0000-0003-0280-0610
Memona JavaidDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0002-7112-9296
Pervaiz Ali ChannarDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0002-0748-0129
Shahid Iqbal FarooqiDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.
Saad AlkahtaniDepartment of Zoology, College of Science, King Saud University, Riyadh 12546, Saudi Arabia.
Jamshed AnwarDepartment of Chemistry, University of Lancaster, Lancaster LA1 4YB, UK.ORCID 0000-0003-1721-0330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidazolidine and thiazolidine-based isatin derivatives (IST-01-04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound-DNA binding by mixed mode of interactions. The evaluated binding parameters, i.e., binding constant (K

Indexed as

Antineoplastic AgentsCell ProliferationDNAHeLa CellsHumansImidazolidinesIsatinMCF-7 CellsMolecular StructureNeoplasmsStructure-Activity RelationshipThiazolidinesAntineoplastic AgentsDNAImidazolidinesIsatinThiazolidinesanticancer drug candidacybinding correlationscell line activityDNA binding studiesisatin derivatives

Identifiers

PMID35056668
PMCPMC8778244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.