Evidence map›Paper›PMID 35056091›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Ion-Pair Compounds of Strychnine for Enhancing Skin Permeability: Influencing the Transdermal Processes In Vitro Based on Molecular Simulation.

Lili He, Di Xiong, Lan Ma, Yan Liang, Teng Zhang, Zhiming Wu, Huaibo Tang, Xuewen Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lili HeDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan 411105, China.
Di XiongDepartment of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.ORCID 0000-0003-2510-8870
Lan MaDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan 411105, China.
Yan LiangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan 411105, China.
Teng ZhangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan 411105, China.
Zhiming WuDepartment of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.ORCID 0000-0002-0618-570X
Huaibo TangDepartment of Pharmacy, School of Chemistry, Xiangtan University, Xiangtan 411105, China.
Xuewen WuDepartment of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Xiangtan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research aimed to explore how Strychnine (Str) ion-pair compounds affect the in vitro transdermal process. In order to prevent the influence of different functional groups on skin permeation, seven homologous fatty acids were selected to form ion-pair compounds with Str. The in vitro permeation fluxes of the Str ion-pair compounds were 2.2 to 8.4 times that of Str, and Str-C

Indexed as

ion-pairmolecular simulationstrychninetransdermal

Identifiers

PMID35056091
PMCPMC8781250
OpenAlexW4200407728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.