ArticlePathogens (Basel, Switzerland)2022
Odontogenic Cervicofacial Necrotizing Fasciitis: Microbiological Characterization and Management of Four Clinical Cases.
Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Brain abscess caused by Actinomyces turicensis in a non-immunocompromised adult patient: a case report and systematic review of the literature.BMC infectious diseases · 2024Pooled it
- Cervical Necrotizing Fasciitis Across the COVID-19 Pandemic: A Single-Center Exploratory Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Pediatric Cervicofacial Necrotizing Fasciitis: A Case Report Highlighting the Diagnostic Challenges and Management in a Child Without Preceding Trauma or Infection.Clinical case reports · 2025Article
- Oral pathologic conditions and impaired cytokine response in patients with previous cerebral abscess or cervical necrotizing soft tissue infection.Frontiers in cellular and infection microbiology · 2025Observational
- Atypical presentation of polymicrobial cervicofacial necrotizing fasciitis: An extraordinary odontogenic infection in a healthy female patient.Clinical case reports · 2024Article
- Article
- Odontogenic infections in the antibiotic era: approach to diagnosis, management, and prevention.Infection · 2024Review
- Polymicrobial infections with specificJournal of oral microbiology · 2024Review
- Serious Complications and Treatment Strategies Associated with Odontogenic Infections.The Eurasian journal of medicine · 2023Article
- Review
- Delayed diagnosis and management of necrotizing fasciitis of the left lower leg: A case report.Medicine · 2022Article
- Odontogenic Submandibular and Descending Necrotising Fasciitis or Myositis - A Case Report on a Clinical Dilemma.Annals of maxillofacial surgeryArticle
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Necrotizing fasciitis of the head and neck is a rare, very severe disease, which, in most cases, originates from odontogenic infections and frequently ends with the death of the patient. Rapid surgical intervention in combination with a preferably pathogen-specific antibiotic therapy can ensure patients' survival. The question arises concerning which pathogens are causative for the necrotizing course of odontogenic inflammations. Experimental 16S-rRNA gene analysis with next-generation sequencing and bioinformatics was used to identify the microbiome of patients treated with an odontogenic necrotizing infection and compared to the result of the routine culture. Three of four patients survived the severe infection, and one patient died due to septic multiorgan failure. Microbiome determination revealed findings comparable to typical odontogenic abscesses. A specific pathogen which could be causative for the necrotizing course could not be identified. Early diagnosis and rapid surgical intervention and a preferably pathogen-specific antibiotic therapy, also covering the anaerobic spectrum of odontogenic infections, are the treatments of choice. The 16S-rRNA gene analysis detected significantly more bacteria than conventional methods; therefore, molecular methods should become a part of routine diagnostics in medical microbiology.
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