ArticleInternational journal of environmental research and public health2022
Biomechanical Characteristics of the Knee Joint during Gait in Obese versus Normal Subjects.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Multibody dynamics-based musculoskeletal modeling for gait analysis: a systematic review.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Kinesiophobia and knee biomechanical characteristics in patients with postoperative tibial plateau fractures across body mass index categories: a cross-sectional mediation analysis.Journal of orthopaedic surgery and research · 2026Article
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- Development and Biomechanical Evaluation of a Modular Knee Prosthesis: From Conceptual V1 Design to an Improved V3 Model.Bioengineering (Basel, Switzerland) · 2026Article
- Knee and ankle kinematics in schoolchildren with different body weights: a cross-sectional study.BMC musculoskeletal disorders · 2026Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- A randomized, double-blind, controlled study on the efficacy of an oral dietary supplement containing fish oil, ASU and phytotherapeutic extracts in canine osteoarthritis.Frontiers in veterinary science · 2025Article
- Association between the Body Roundness Index and osteoarthritis: A population-based study.PloS one · 2025Article
- Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases.Bone research · 2024Review
- Unveiling the Hidden Links: Anatomical and Radiological Insights into Primary Hip Osteoarthritis.Journal of personalized medicine · 2024Article
- The effect of body weight on the knee joint biomechanics based on subject-specific finite element-musculoskeletal approach.Scientific reports · 2024Article
- Effect of different constraining boundary conditions on simulated femoral stresses and strains during gait.Scientific reports · 2024Article
- Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review.Orthopaedic surgery · 2024Review
- Comparison of ground reaction forces as running speed increases between male and female runners.Frontiers in bioengineering and biotechnology · 2024Article
- PSD95 as a New Potential Therapeutic Target of Osteoarthritis: A Study of the Identification of Hub Genes through Self-Contrast Model.International journal of molecular sciences · 2023Article
- Knee joint biomechanics and cartilage damage prediction during landing: A hybrid MD-FE-musculoskeletal modeling.PloS one · 2023Article
- Lightweight convolutional neural network (CNN) model for obesity early detection using thermal images.Digital healthArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (OA) is a growing source of pain and disability. Obesity is the most important avoidable risk factor underlying knee OA. The processes by which obesity impacts osteoarthritis are of tremendous interest to osteoarthritis researchers and physicians, where the joint mechanical load is one of the pathways generally thought to cause or intensify the disease process. In the current work, we developed a hybrid framework that simultaneously incorporates a detailed finite element model of the knee joint within a musculoskeletal model to compute lower extremity muscle forces and knee joint stresses in normal-weight (N) and obese (OB) subjects during the stance phase gait. This model accounts for the synergy between the active musculature and passive structures. In comparing OB subjects and normal ones, forces significantly increased in all muscle groups at most instances of stance. Mainly, much higher activation was computed with lateral hamstrings and medial gastrocnemius. Cartilage contact average pressure was mostly supported by the medial plateau and increased by 22%, with a larger portion of the load transmitted via menisci. This medial compartment experienced larger relative movement and cartilage stresses in the normal subjects and continued to do so with a higher level in the obese subjects. Finally, the developed bioengineering frame and the examined parameters during this investigation might be useful clinically in evaluating the initiation and propagation of knee OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.