Evidence map›Paper›PMID 35055807›Full record

Trial reportInternational journal of environmental research and public health2022

The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial.

Biagio Rapone, Elisabetta Ferrara, Luigi Santacroce, Skender Topi, Antonio Gnoni, Gianna Dipalma, Antonio Mancini, Marina Di Domenico, Gianluca Martino Tartaglia, Antonio Scarano and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05447026 (The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis), which is not on this map. Cited by 47 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 11 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05447026 nacompletednot on this map

The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis

TypeinterventionalSponsorGazi UniversityRan2018 to 2022Enrolled48ConditionsPeriodontitis, Lasers, Ozone, Wound HealingArmsControl group, Antimicrobial photodynamic therapy (aPDT) group, LED photobiomodulation group, Topical ozone group
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 11 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  10. Periodontal Disease in Patients with Psoriasis: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Biagio RaponeInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, 70121 Bari, Italy.ORCID 0000-0002-0062-6594
Elisabetta FerraraComplex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy.ORCID 0000-0002-4831-4098
Luigi SantacroceComplex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy.ORCID 0000-0001-5671-8124
Skender TopiDepartment of Clinical Disciplines, School of Technical Medical Sciences, University A. Xhuvani, 3001 Elbasan, Albania.
Antonio GnoniDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari, 70121 Bari, Italy.
Gianna DipalmaInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, 70121 Bari, Italy.ORCID 0000-0002-5947-8987
Antonio ManciniInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, 70121 Bari, Italy.ORCID 0000-0002-7103-4086
Marina Di DomenicoDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Gianluca Martino TartagliaUOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy.
Antonio ScaranoDepartment of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Francesco InchingoloInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, 70121 Bari, Italy.ORCID 0000-0003-3797-5883
University of Bari Aldo Moro · ITOspedale SS. Annunziata · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Chieti-Pescara · ITUniversity of Elbasan · ALUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundthe establishment of periodontitis is regulated by the primary etiological factor and several individual conditions including the immune response mechanism of the host and individual genetic factors. It results when the oral homeostasis is interrupted, and biological reactions favor the development and progression of periodontal tissues damage. Different strategies have been explored for reinforcing the therapeutic effect of non-surgical periodontal treatment of periodontal tissue damage. Gaseous ozone therapy has been recognized as a promising antiseptic adjuvant, because of its immunostimulating, antimicrobial, antihypoxic, and biosynthetic effects. Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote the tissue healing response.

methodsto test this hypothesis, we conducted a prospective randomized study comparing non-surgical periodontal treatment plus gaseous ozone therapy to standard therapy. A total of 90 healthy individuals with moderate or severe generalized periodontitis were involved in the study. The trial was conducted from September 2019 to October 2020. Forty-five patients were randomized to receive scaling and root-planning (SRP) used as conventional non-surgical periodontal therapy plus gaseous ozone therapy (GROUP A); forty-five were allocated to standard treatment (GROUP B). The endpoint was defined as the periodontal response rate after the application of the ozone therapy at 3 months and 6 months, defined as no longer meeting the criteria for active periodontitis. Statistical analysis was performed employing SPSS v.18 Chicago: SPSS Inc.

resultsperiodontal parameters differed significantly between patients treated with the two distinct procedures at 3 months (

conclusionsThe present study suggests that SRP combined with ozone therapy in the treatment of periodontitis revealed an improved outcome than SRP alone.

Indexed as

Anti-Infective Agents, LocalChronic PeriodontitisOzonePeriodontitisHumansPeriodontal IndexProspective StudiesTreatment OutcomeAnti-Infective Agents, LocalOzonegaseous ozone therapymoderate periodontitisnon-surgical periodontal treatmentozoneperiodontal diseasesevere periodontitis

Identifiers

PMID35055807
PMCPMC8775443
OpenAlexW4205453336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.