Evidence map›Paper›PMID 35055391›Full record

ArticleJournal of personalized medicine2022

Integration of Genomic Risk Scores to Improve the Prediction of Childhood Asthma Diagnosis.

Dilini M Kothalawala, Latha Kadalayil, John A Curtin, Clare S Murray, Angela Simpson, Adnan Custovic, William J Tapper, S Hasan Arshad, Faisal I Rezwan, John W Holloway and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Association of urinary eosinophilic protein X at age 3 years and subsequent persistence of wheezing and asthma diagnosis in adolescence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  8. Asthma-Genomic Advances Toward Risk Prediction.Clinics in chest medicine · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023
    Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Dilini M KothalawalaHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-5804-0457
Latha KadalayilHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
John A CurtinDivision of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Manchester University Hospital NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.
Clare S MurrayDivision of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Manchester University Hospital NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.
Angela SimpsonDivision of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Manchester University Hospital NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.
Adnan CustovicNational Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, London SW3 6LY, UK.ORCID 0000-0001-5218-7071
William J TapperHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
S Hasan ArshadNIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Faisal I RezwanHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0001-9998-0464
On Behalf Of Stelar/Unicorn Investigators
Manchester Academic Health Science Centre · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Southampton · GBAberystwyth University · GBImperial College London · GB

Funding

Medical Research Council G0601361Medical Research Council MR/K002449/1Medical Research Council MR/L012693/1Medical Research Council MR/S025340/1Medical Research Council UNICORN (Unified Cohorts Research Network): Disaggregating asthma (MR/S025340/1)
6 · The paper itself

Abstract

Genome-wide and epigenome-wide association studies have identified genetic variants and differentially methylated nucleotides associated with childhood asthma. Incorporation of such genomic data may improve performance of childhood asthma prediction models which use phenotypic and environmental data. Using genome-wide genotype and methylation data at birth from the Isle of Wight Birth Cohort (

Indexed as

asthmachildhooddata integrationmachine learningmethylation risk scorepolygenic risk scoreprediction

Identifiers

PMID35055391
PMCPMC8777841
OpenAlexW4205600478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.