ArticleJournal of personalized medicine2022
The Role of Cumulative LDL Cholesterol in Cardiovascular Disease Development in Patients with Familial Hypercholesterolemia.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Efficacy and safety of Tafolecimab in Chinese patients with type 2 diabetes and hypercholesterolemia: a post-hoc analysis of pooled data from three phase 3 trials.Cardiovascular diabetology · 2025Trial
- Prevalence and determinants of dyslipidemia among residents of Kurdistan Region of Iraq; a community-based study.BMC research notes · 2026Article
- LDL cholesterol burden in elderly patients with familial hypercholesterolemia: Insights from real-world data.American journal of preventive cardiology · 2025Article
- In-hospital and mid-term follow-up of low-density lipoprotein cholesterol and target-goal attainment among patients with acute cerebral infarction: a retrospective study.Lipids in health and disease · 2024Article
- Basic Research in Atherosclerosis: Technologies of Personalized Medicine.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
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Abstract
In patients with familial hypercholesterolemia (FH) the exposure of very high LDL-C concentration and cumulative LDL-C level (cum LDL-C) can play a significant role in the prognosis.
objectiveto analyze the contribution of "cum LDL-C for all life" and the index "cum LDL-C/age" to the development of coronary heart disease (CHD), myocardial infarction (MI), and a combined end point: MI, stroke, unstable angina in FH patients.
methods188 patients (mean age 49.2 years, males 45.7%) with FH were examined (Dutch Lipid Clinic Criteria). We had evaluated cumulative LDL-C and index "cum DL-C/age" along with other classical risk factors. Cum LDL-C was calculated as LDL-Cmax × (age at initiating of hypolipidemic therapy) + LDL-C at inclusion age at initiation/correction therapy). Cumulative LDL-C and "cum LDL-C/age" were calculated as the ratio cum LDL-C to age. The follow-up period was 5.4 (from 3 to 10) years.
resultsThe index "cum LDL-C/age" was higher in patients with CHD 58.7 ± 10.4 mmol/L/years vs. 40.1 ± 11.7 mmol/L/years in patients without CHD (
conclusioncumulative LDL-C level plays an important role in the development of CHD in FH patients.
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