Evidence map›Paper›PMID 35055324›Full record

ReviewJournal of personalized medicine2021

MRI in Pregnancy and Precision Medicine: A Review from Literature.

Gianluca Gatta, Graziella Di Grezia, Vincenzo Cuccurullo, Celestino Sardu, Francesco Iovino, Rosita Comune, Angelo Ruggiero, Marilena Chirico, Daniele La Forgia, Annarita Fanizzi and 8 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gianluca GattaSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Graziella Di GreziaRadiology Department, G. Criscuoli Hospital, 83054 Sant'Angelo dei Lombardi, Italy.
Vincenzo CuccurulloNuclear Medicine Unit, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0003-0474-7163
Celestino SarduDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0001-5099-3790
Francesco IovinoDepartment of Translational Medical Science, School of Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Rosita ComuneSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Angelo RuggieroDepartment of Public Health, Pharmaceutical Use and Dermatology, University of Naples Federico II, 80138 Naples, Italy.ORCID 0000-0002-4658-7391
Marilena ChiricoDepartment of Anesthesiology and Intensive Care Medicine, University of Naples Federico II, 80138 Naples, Italy.
Daniele La ForgiaDepartment of Breast Radiology, Giovanni Paolo II/I.R.C.C.S. Cancer Institute, 70124 Bari, Italy.ORCID 0000-0002-3902-4523
Annarita FanizziDepartment of Breast Radiology, Giovanni Paolo II/I.R.C.C.S. Cancer Institute, 70124 Bari, Italy.ORCID 0000-0002-2729-9896
Raffaella MassafraDepartment of Breast Radiology, Giovanni Paolo II/I.R.C.C.S. Cancer Institute, 70124 Bari, Italy.ORCID 0000-0001-8588-261X
Maria Paola BelfioreSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Giuseppe FalcoBreast Surgery Unit, Department of Oncology and Advanced Technologies, IRCSS Santa Maria Nuova Hospital, 42123 Reggio Emilia, Italy.
Alfonso ReginelliSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Luca BruneseMedicine and Health Science Department, University of Molise, 86100 Campobasso, Italy.
Roberto GrassiSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Salvatore CappabiancaSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Luigi ViolaSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.

Funding

Italian Ministry of Health "Ricerca Finalizzata 2018"
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) offers excellent spatial and contrast resolution for evaluating a wide variety of pathologies, without exposing patients to ionizing radiations. Additionally, MRI offers reproducible diagnostic imaging results that are not operator-dependent, a major advantage over ultrasound. MRI is commonly used in pregnant women to evaluate, most frequently, acute abdominal and pelvic pain or placental abnormalities, as well as neurological or fetal abnormalities, infections, or neoplasms. However, to date, our knowledge about MRI safety during pregnancy, especially about the administration of gadolinium-based contrast agents, which are able to cross the placental barrier, is still limited, raising concerns about possible negative effects on both the mother and the health of the fetus. Contrast agents that are unable to cross the placenta in a way that is safe for the fetus are desirable. In recent years, some preclinical studies, carried out in rodent models, have evaluated the role of long circulating liposomal nanoparticle-based blood-pool gadolinium contrast agents that do not penetrate the placental barrier due to their size and therefore do not expose the fetus to the contrast agent during pregnancy, preserving it from any hypothetical risks. Hence, we performed a literature review focusing on contrast and non-contrast MRI use during pregnancy.

Indexed as

gadoliniumliposomal gadoliniumMRIprecision medicinepregnancysafety during pregnancy

Identifiers

PMID35055324
PMCPMC8778056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.