Evidence map›Paper›PMID 35055241›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Resveratrol Nanocrystal Incorporated into Mesoporous Material: Rational Design and Screening through Quality-by-Design Approach.

Ahmad Ainurofiq, Yuniawan Hidayat, Eva Y P Lestari, Mayasri M W Kumalasari, Syaiful Choiri

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmad AinurofiqPharmaceutical Technology and Drug Delivery, Department of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta 57126, Indonesia.ORCID 0000-0003-2880-5321
Yuniawan HidayatDepartment of Chemistry, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta 57126, Indonesia.
Eva Y P LestariDepartment of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta 57126, Indonesia.
Mayasri M W KumalasariDepartment of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta 57126, Indonesia.
Syaiful ChoiriPharmaceutical Technology and Drug Delivery, Department of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta 57126, Indonesia.ORCID 0000-0001-7750-6008

Funding

Universitas Sebelas Maret, Ministry of Education, Culture, Research, and Technology 260/UN27.22/HK.07.00/2021
6 · The paper itself

Abstract

Bioflavonoids from grape seeds feature powerful antioxidant and immunostimulant activities, but they present problems related to solubility and bioavailability. Nanocrystal (NC) incorporated into a mesoporous carrier is a promising strategy to address these issues. However, the preparation of this formulation involves the selection of factors affecting its critical quality attributes. Hence, this study aimed to develop an NC formulation incorporating resveratrol into a soluble mesoporous carrier based on rational screening design using a systematic and continuous development process, the quality-by-design paradigm. A mesoporous soluble carrier was prepared by spray-drying mannitol and ammonium carbonate. The NC was obtained by introducing the evaporated solvent containing a drug/polymer/surfactant and mesoporous carrier to the medium. A 2

Indexed as

fractional factorial designnanocrystalpolymersresveratrol

Identifiers

PMID35055241
PMCPMC8779882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.