ArticleInternational journal of molecular sciences2022
Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure.
Evelyn M Templeton, Moritz Lassé, Torsten Kleffmann, Leigh J Ellmers, Suetonia C Palmer, Trent Davidson, Nicola J A Scott, John W Pickering, Christopher J Charles, Zoltan H Endre and 4 more
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 3 institutions in 3 countries.
Evelyn M TempletonChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.ORCID 0000-0002-5767-794X Moritz LasséChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.ORCID 0000-0001-5735-9549 Torsten KleffmannResearch Infrastructure Centre, Division of Health Sciences, University of Otago, Dunedin 9016, New Zealand.
Leigh J EllmersChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.
Suetonia C PalmerDepartment of Medicine, University of Otago, Christchurch 8014, New Zealand.
Trent DavidsonDepartment of Anatomical Pathology, Prince of Wales Hospital, Sydney, NSW 2031, Australia.
Nicola J A ScottChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.ORCID 0000-0002-5685-9151 John W PickeringChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.
Christopher J CharlesChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.ORCID 0000-0001-9807-8022 Zoltan H EndreDepartment of Nephrology, Prince of Wales Hospital, Sydney, NSW 2031, Australia.
Vicky A CameronChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.ORCID 0000-0003-3147-683X A Mark RichardsChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.
Miriam T RademakerChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.
Anna P PilbrowChristchurch Heart Institute, Department of Medicine, University of Otago, Christchurch 8014, New Zealand.
University of Otago · NZPrince of Wales Hospital · AUNational University of Singapore · SG
Funding
Health Research Council of New Zealand 11/170Health Research Council of New Zealand 14/521Health Research Council of New Zealand 17/562Lotteries Health Research R-LHR-2017-49246National Heart Foundation of New Zealand 1562National Heart Foundation of New Zealand 1693National Heart Foundation of New Zealand 1838National Heart Foundation of New Zealand 1879
6 · The paper itselfAbstract
One-quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI)-an abrupt reduction or loss of kidney function associated with increased long-term mortality. There is a critical need to identify early and real-time markers of AKI in ADHF; however, to date, no protein biomarkers have exhibited sufficient diagnostic or prognostic performance for widespread clinical uptake. We aimed to identify novel protein biomarkers of AKI associated with ADHF by quantifying changes in protein abundance in the kidneys that occur during ADHF development and recovery in an ovine model. Relative quantitative protein profiling was performed using sequential window acquisition of all theoretical fragment ion spectra-mass spectrometry (SWATH-MS) in kidney cortices from control sheep (
Indexed as
Acute Kidney InjuryAnimalsBiomarkersDisease Models, AnimalHeart FailureHumansPlatelet Membrane GlycoproteinsPrognosisProteomicsSheepBiomarkersPlatelet Membrane Glycoproteinsplatelet membrane glycoprotein VIacute decompensated heart failureacute kidney injuryacute renal failurebiomarkerCCTCCT6Aheart failureproteomicsSWATH–MSTRiC
Identifiers
PMID35055195
PMCPMC8778509
OpenAlexW4225889710
What OpenQuestion holds
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LicenceCC BY
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