ArticleInternational journal of molecular sciences2022
Engineering of Injectable Antibiotic-laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.Cell and tissue banking · 2026Review
- Immunomodulatory and pro-mineralizing effects of an injectable baicalein-loaded methacrylated gelatin hydrogel for vital pulp therapy.Biomaterials advances · 2026Article
- Modern Drug Delivery Platforms Based on Photocrosslinkable Hydrogels (PCHs) in Dentistry: From Material Characteristics to Clinical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Visualization Analysis and Knowledge Structure Evolution of Hydrogel Applications in Dentistry.International dental journal · 2026Article
- Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions.Journal of nanobiotechnology · 2025Article
- Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine.Macromolecular bioscience · 2025Review
- Antibacterial and biocompatibility properties of bioactive glass and double antibiotic-loaded hydrogels in regenerative endodontic treatment.Scientific reports · 2025Article
- Electrospun nanofibers: Focus on local therapeutic delivery targeting infectious disease.Journal of drug delivery science and technology · 2025Article
- Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases.Biomaterial investigations in dentistry · 2025Article
- Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration.Theranostics · 2025Review
- Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Article
- GelMA/TCP nanocomposite scaffold for vital pulp therapy.Acta biomaterialia · 2024Article
- Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine.International journal of molecular sciences · 2023Review
- Engineering the Future of Dental Health: Exploring Molecular Advancements in Dental Pulp Regeneration.International journal of molecular sciences · 2023Article
- Nanoscale β-TCP-Laden GelMA/PCL Composite Membrane for Guided Bone Regeneration.ACS applied materials & interfaces · 2023Article
- Multifunctional and biodegradable methacrylated gelatin/Aloe vera nanofibers for endodontic disinfection and immunomodulation.Biomaterials advances · 2023Article
- Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases.Gels (Basel, Switzerland) · 2023Review
- Article
- Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication.Odontology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
This study aimed at engineering cytocompatible and injectable antibiotic-laden fibrous microparticles gelatin methacryloyl (GelMA) hydrogels for endodontic infection ablation. Clindamycin (CLIN) or metronidazole (MET) was added to a polymer solution and electrospun into fibrous mats, which were processed via cryomilling to obtain CLIN- or MET-laden fibrous microparticles. Then, GelMA was modified with CLIN- or MET-laden microparticles or by using equal amounts of each set of fibrous microparticles. Morphological characterization of electrospun fibers and cryomilled particles was performed via scanning electron microscopy (SEM). The experimental hydrogels were further examined for swelling, degradation, and toxicity to dental stem cells, as well as antimicrobial action against endodontic pathogens (agar diffusion) and biofilm inhibition, evaluated both quantitatively (CFU/mL) and qualitatively via confocal laser scanning microscopy (CLSM) and SEM. Data were analyzed using ANOVA and Tukey's test (α = 0.05). The modification of GelMA with antibiotic-laden fibrous microparticles increased the hydrogel swelling ratio and degradation rate. Cell viability was slightly reduced, although without any significant toxicity (cell viability > 50%). All hydrogels containing antibiotic-laden fibrous microparticles displayed antibiofilm effects, with the dentin substrate showing nearly complete elimination of viable bacteria. Altogether, our findings suggest that the engineered injectable antibiotic-laden fibrous microparticles hydrogels hold clinical prospects for endodontic infection ablation.
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Registered trials
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