Evidence map›Paper›PMID 35055125›Full record

ArticleInternational journal of molecular sciences2022

NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH.

René St-Arnaud, Martin Pellicelli, Mahmoud Ismail, Alice Arabian, Toghrul Jafarov, Chengji J Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

René St-ArnaudResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0003-1016-1580
Martin PellicelliResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.
Mahmoud IsmailResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0001-6676-6437
Alice ArabianResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.
Toghrul JafarovResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.
Chengji J ZhouDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-8592-4680
Shriners Hospitals for Children - Canada · CAShriners Hospitals for Children - Northern California · US

Funding

Shriners Hospitals for Children 85100
6 · The paper itself

Abstract

PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene

Indexed as

Anabolic AgentsAnimalsCell LineCell MembraneEmbryonic Stem CellsGene Expression RegulationGene Knock-In TechniquesLow Density Lipoprotein Receptor-Related Protein-6MiceMolecular ChaperonesMutagenesis, Site-DirectedOsteoblastsOsteocytesParathyroid HormonePhosphorylationSignal TransductionAnabolic AgentsLow Density Lipoprotein Receptor-Related Protein-6Lrp6 protein, mouseMolecular Chaperonesnascent-polypeptide-associated complexParathyroid HormoneboneLRP6NACAosteoblastsosteocytesparathyroid hormone

Identifiers

PMID35055125
PMCPMC8780913
OpenAlexW4206063784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.