Evidence map›Paper›PMID 35055107›Full record

ArticleInternational journal of molecular sciences2022

TNF-α Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis.

Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Yu-Wen Cheng, Chung-Yuan Hsu, Wen-Yi Chou, Chang-Chun Hsiao, Chih-Hung Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shang-Hung LinDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Ji-Chen HoDepartment of Dermatology, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 613, Taiwan.
Sung-Chou LiGenomics and Proteomics Core Laboratory, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-3016-9718
Yu-Wen ChengDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chung-Yuan HsuDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0003-1207-646X
Wen-Yi ChouDepartment of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chang-Chun HsiaoGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-7275-4675
Chih-Hung LeeDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0001-9804-3874
Chang Gung University · TW

Funding

Chang-Gung Memorial Foundation CMRPG8J0411Ministry of Science and Technology of Taiwan MOST 108-2314-B-182A-105 -MY3
6 · The paper itself

Abstract

Psoriatic arthritis (PsA) results from joint destruction by osteoclasts. The promising efficacy of TNF-α blockage indicates its important role in osteoclastogenesis of PsA. WNT ligands actively regulate osteoclastogenesis. We investigated how WNT ligands activate osteoclasts amid the TNF-α milieu in PsA. We first profiled the expression of WNT ligands in CD14

Indexed as

AdultArthritis, PsoriaticCase-Control StudiesCell MovementChemokine CCL2FemaleHumansLipopolysaccharide ReceptorsMaleMiddle AgedOsteoclastsTHP-1 CellsTumor Necrosis Factor-alphaUp-RegulationWnt-5a ProteinCCL2 protein, humanCD14 protein, humanChemokine CCL2Lipopolysaccharide ReceptorsTNF protein, humanTumor Necrosis Factor-alphaWnt-5a ProteinWNT5A protein, humananti-IL-17 agentsanti-TNF-α agentsMCP-1osteoclastogenesisosteoclast precursorspsoriatic arthritisTNF-αWNT5A upregulation

Identifiers

PMID35055107
PMCPMC8778693
OpenAlexW4205336354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.