Evidence map›Paper›PMID 35055066›Full record

ArticleInternational journal of molecular sciences2022

The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23.

Annalisa Chianese, Carla Zannella, Alessandra Monti, Anna De Filippis, Nunzianna Doti, Gianluigi Franci, Massimiliano Galdiero

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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  8. Review
  9. Outer membrane vesicles fromFrontiers in molecular biosciences · 2025
    Article
  10. ScymicrosinFrontiers in microbiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Oreoch-1: A Peptide fromPathogens (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Annalisa ChianeseDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1648-4519
Carla ZannellaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7991-8700
Alessandra MontiInstitute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80134 Naples, Italy.
Anna De FilippisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-0395-7962
Nunzianna DotiInstitute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80134 Naples, Italy.
Gianluigi FranciDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-3321-4331
Massimiliano GaldieroDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1576-6290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections represent a serious threat to the world population and are becoming more frequent. The search and identification of broad-spectrum antiviral molecules is necessary to ensure new therapeutic options, since there is a limited availability of effective antiviral drugs able to eradicate viral infections, and consequently due to the increase of strains that are resistant to the most used drugs. Recently, several studies on antimicrobial peptides identified them as promising antiviral agents. In detail, amphibian skin secretions serve as a rich source of natural antimicrobial peptides. Their antibacterial and antifungal activities have been widely reported, but their exploitation as potential antiviral agents have yet to be fully investigated. In the present study, the antiviral activity of the peptide derived from the secretion of

Indexed as

Amphibian ProteinsAnimalsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntiviral AgentsCell SurvivalChlorocebus aethiopsDNA VirusesRanidaeRNA VirusesSARS-CoV-2Vero CellsViral EnvelopeViral Plaque AssayVirus DiseasesAmphibian ProteinsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntiviral AgentsAR-23 peptide, Rana fagoiantimicrobial peptidesantiviral drugsantiviral therapycoronavirusHSV-1SARS-CoV-2

Identifiers

PMID35055066
PMCPMC8779559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.