Evidence map›Paper›PMID 35055057›Full record

ReviewInternational journal of molecular sciences2022

Emerging Advances of Detection Strategies for Tumor-Derived Exosomes.

Huijuan Cheng, Qian Yang, Rongrong Wang, Ruhua Luo, Shanshan Zhu, Minhui Li, Wenqi Li, Cheng Chen, Yuqing Zou, Zhihua Huang and 4 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Exosomes: a promising avenue for cancer diagnosis beyond treatment.Frontiers in cell and developmental biology · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huijuan ChengCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Qian YangCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Rongrong WangCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-1039-3333
Ruhua LuoCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0001-5635-2636
Shanshan ZhuPublic Health Institutes, Hangzhou Normal University, Hangzhou 311121, China.
Minhui LiCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Wenqi LiCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Cheng ChenCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yuqing ZouCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Zhihua HuangCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Tian XieCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0001-7066-1443
Shuling WangCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Honghua ZhangCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Qingchang TianCollege of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-3672-0099

Funding

Joint Funds of the Zhejiang Provincial Natural Science Foundation of China LHDMZ22H300001Key projects of National Natural Science Foundation of China 81730108Key Research Project of Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program 2022ZZ024National Natural Science Foundation of China 82074052Zhejiang Provincial Natural Science Foundation of China LY20H160008
6 · The paper itself

Abstract

Exosomes derived from tumor cells contain various molecular components, such as proteins, RNA, DNA, lipids, and carbohydrates. These components play a crucial role in all stages of tumorigenesis and development. Moreover, they reflect the physiological and pathological status of parental tumor cells. Recently, tumor-derived exosomes have become popular biomarkers for non-invasive liquid biopsy and the diagnosis of numerous cancers. The interdisciplinary significance of exosomes research has also attracted growing enthusiasm. However, the intrinsic nature of tumor-derived exosomes requires advanced methods to detect and evaluate the complex biofluid. This review analyzes the relationship between exosomes and tumors. It also summarizes the exosomal biological origin, composition, and application of molecular markers in clinical cancer diagnosis. Remarkably, this paper constitutes a comprehensive summary of the innovative research on numerous detection strategies for tumor-derived exosomes with the intent of providing a theoretical basis and reference for early diagnosis and clinical treatment of cancer.

Indexed as

Biomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNADisease SusceptibilityEarly Detection of CancerExosomesHumansLiquid BiopsyMolecular Diagnostic TechniquesNeoplasmsOncogene ProteinsSELEX Aptamer TechniqueSpectrum Analysis, RamanBiomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNAOncogene Proteinsdetection methodsexosomesmolecular biomarkerstumor-derived exosomes

Identifiers

PMID35055057
PMCPMC8775838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.