Evidence map›Paper›PMID 35055051›Full record

ArticleInternational journal of molecular sciences2022

Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity.

Jinsoo Kim, Dohee Ahn, Sang J Chung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Effect of Thai Herbal Remedy NL Inhibits Lipid Accumulation on 3T3-L1 Adipocyte Cells.Advances in pharmacological and pharmaceutical sciences · 2024
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jinsoo KimSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0001-9382-5527
Dohee AhnSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0001-6661-5129
Sang J ChungSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-3501-212X
Sungkyunkwan University · KR

Funding

National Research Foundation of Korea NRF-2012M3A9C4048775National Research Foundation of Korea NRF-2017M3A9C8031995
6 · The paper itself

Abstract

Depletion of protein phosphatase-1 catalytic subunit beta (PPP1CB), a serine/threonine protein phosphatase and potent adipogenic activator, suppresses the differentiation of 3T3-L1 preadipocytes into mature adipocytes. Therefore, PPP1CB is considered as a potential therapeutic target for obesity. We screened 1033 natural products for PPP1CB inhibitors and identified chebulinic acid, which is abundantly present in the seeds of

Indexed as

3T3-L1 CellsAdipocytesAdipogenesisAdipokinesAnimalsAnti-Obesity AgentsBiological ProductsCell SurvivalEnzyme ActivationEnzyme InhibitorsGene Expression RegulationHydrolyzable TanninsMiceMolecular StructureProtein Phosphatase 1Recombinant ProteinsAdipokinesAnti-Obesity AgentsBiological Productschebulinic acidEnzyme InhibitorsHydrolyzable TanninsPpp1cc protein, mouseProtein Phosphatase 1Recombinant ProteinsTranscription Factors3T3-L1 adipocyteadipogenesischebulinic acidnatural productobesityPPP1CB

Identifiers

PMID35055051
PMCPMC8775935
OpenAlexW4205327949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.