Evidence map›Paper›PMID 35055036›Full record

ArticleInternational journal of molecular sciences2022

Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes.

Ruiyi Ren, Anne A Humphrey, David L Swain, Haiyan Gong

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 9 citations in OpenAlex.

  1. Novel Role for CGRP in Aqueous Humor Outflow.Investigative ophthalmology & visual science · 2026
    Article
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  9. Segmental Unconventional Outflow in Mouse Eyes.Investigative ophthalmology & visual science · 2023
    Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ruiyi RenDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-5785-2165
Anne A HumphreyDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.
David L SwainDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0003-3969-9712
Haiyan GongDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-7204-5019
Boston University · US

Funding

Cellular Physiology of the Aqueous Outflow PathwayR01EY022634 · NEI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GONG, HAIYAN · 2012 to 2020
$3.7M
Massachusetts Lions Eye Research Fund 2016NEI NIH HHS R01 EY022634NIH HHS EY022634
6 · The paper itself

Abstract

We investigated whether an inverse relationship exists between intraocular pressure (IOP) and effective filtration area (EFA) in the trabecular meshwork (TM) in a steroid-induced ocular hypertensive (SIOH) mouse model and the morphological changes associated with the reduction of EFA. C57BL/6 mice (

Indexed as

Intraocular PressureAnimalsBasement MembraneBiomarkersBody WeightDexamethasoneDisease Models, AnimalDisease SusceptibilityFluorescent Antibody TechniqueGlaucomaMiceSteroidsTrabecular MeshworkBiomarkersDexamethasoneSteroidsconfocal microscopyeffective filtration areaintraocular pressuremorphologysteroid-induced ocular hypertensive mouse modeltrabecular meshworktransmission electron microscopy

Identifiers

PMID35055036
PMCPMC8775853
OpenAlexW4205363497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.