Evidence map›Paper›PMID 35055028›Full record

ArticleInternational journal of molecular sciences2022

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway.

Myun Soo Kim, Dongmin Park, Sora Lee, Sunyoung Park, Kyung Eun Kim, Tae Sung Kim, Hyun Jeong Park, Daeho Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Myun Soo KimKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.
Dongmin ParkKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.
Sora LeeKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.
Sunyoung ParkKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.ORCID 0000-0002-5035-2931
Kyung Eun KimDepartment of Cosmetic Sciences, Sookmyung Women's University, Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul 04310, Korea.ORCID 0000-0003-2201-1280
Tae Sung KimDivision of Life Sciences, College of Life Sciences and Biotechnology, Korea University, 5-ga, Anam-dong, Seongbuk-gu, Seoul 02841, Korea.ORCID 0000-0002-0384-4407
Hyun Jeong ParkKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.
Daeho ChoKine Sciences, 525, Seolleung-ro, Gangnam-gu, Seoul 06149, Korea.ORCID 0000-0002-6996-7557
Korea University · KRSookmyung Women's University · KR

Funding

Korea University Q1826341
6 · The paper itself

Abstract

Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca

Indexed as

Signal TransductionAnimalsBiomarkersCalciumCalcium SignalingCell DifferentiationImmunophenotypingLymphocyte ActivationMembrane ProteinsMicePhospholipase C gammaPhosphorylationReceptors, Antigen, T-CellT-LymphocytesT-Lymphocyte SubsetsTumor Suppressor ProteinsBiomarkersCalciumerythroid differentiation regulator 1, mouseMembrane ProteinsPhospholipase C gammaPlcg1 protein, mouseReceptors, Antigen, T-CellTumor Suppressor ProteinsErdr1PLCγ1TCR signal modulation

Identifiers

PMID35055028
PMCPMC8776247
OpenAlexW4205896658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.