Evidence map›Paper›PMID 35054929›Full record

ArticleInternational journal of molecular sciences2022

G-Quadruplex Regulation of

Kangkang Niu, Xiaojuan Zhang, Qisheng Song, Qili Feng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. RNA Regulatory Networks 2.0.International journal of molecular sciences · 2023
    Article
  10. Review
  11. Secondary structures in RNA synthesis, splicing and translation.Computational and structural biotechnology journal · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kangkang NiuGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, China.
Xiaojuan ZhangGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, China.
Qisheng SongDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USA.
Qili FengGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, China.
South China Normal University · CNUniversity of Missouri · US

Funding

China National Postdoctoral Program for Innovative Talents BX20190123National Natural Science Foundation of China 31720103916,32000337,31930102
6 · The paper itself

Abstract

In eukaryotes, mRNAs translation is mainly mediated in a cap-dependent or cap-independent manner. The latter is primarily initiated at the internal ribosome entry site (IRES) in the 5'-UTR of mRNAs. It has been reported that the G-quadruplex structure (G4) in the IRES elements could regulate the IRES activity. We previously confirmed RBM4 (also known as LARK) as a G4-binding protein in human. In this study, to investigate whether RBM4 is involved in the regulation of the IRES activity by binding with the G4 structure within the IRES element, the IRES-A element in the 5'-UTR of vascular endothelial growth factor A (

Indexed as

G-QuadruplexesProtein Biosynthesis5' Untranslated RegionsGene ExpressionGene Expression RegulationGenes, ReporterHEK293 CellsHumansInternal Ribosome Entry SitesRNA-Binding ProteinsRNA, MessengerVascular Endothelial Growth Factor A5' Untranslated RegionsInternal Ribosome Entry SitesRBM4 protein, humanRNA-Binding ProteinsRNA, MessengerVascular Endothelial Growth Factor AVEGFA protein, humanG-quadruplexIRESmRNA translationVEGFA

Identifiers

PMID35054929
PMCPMC8776124
OpenAlexW4206032525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.