Evidence map›Paper›PMID 35054915›Full record

ArticleInternational journal of molecular sciences2022

eDNA Inactivation and Biofilm Inhibition by the PolymericBiocide Polyhexamethylene Guanidine Hydrochloride (PHMG-Cl).

Olena V Moshynets, Taras P Baranovskyi, Olga S Iungin, Nadiia P Kysil, Larysa O Metelytsia, Ianina Pokholenko, Viktoria V Potochilova, Geert Potters, Kateryna L Rudnieva, Svitlana Y Rymar and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Surface Carrier Testing of Hospital Antiseptics AgainstPathogens (Basel, Switzerland) · 2026
    Article
  2. Polyhexamethylene guanidine hydrochloride as active ingredient for anticariogenic products: studies in vitro and in vivo.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  3. Synthesis and Biological Activity of Guanidine Scaffold: A Comprehensive Review.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026
    Review
  4. Article
  5. Article
  6. Microbiological and toxicity analyses of the synthetic polymer polyhexamethylene guanidine hydrochloride against endodontic microorganisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Antimicrobial polymer-loaded hydrogels for the topical treatment of multidrug-resistant wound biofilm infections.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  13. KACS omega · 2023
    Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Olena V MoshynetsBiofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine.ORCID 0000-0002-2209-8681
Taras P BaranovskyiDepartment of Dermatovenerology, Allergology, Clinical and Laboratory Immunology, Shupyk National Healthcare University of Ukraine, 9 Dorohozhytska Str., 03680 Kiev, Ukraine.ORCID 0000-0001-9248-4097
Olga S IunginBiofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine.ORCID 0000-0001-8876-6075
Nadiia P KysilNational Children's Specialized Hospital "Okhmatdyt", 28/1 Chornovola Str., 01135 Kiev, Ukraine.
Larysa O MetelytsiaV. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine.
Ianina PokholenkoBiofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine.ORCID 0000-0003-1608-1258
Viktoria V PotochilovaKyiv Regional Clinical Hospital, 1 Baggovutivska Street, 04107 Kiev, Ukraine.
Geert PottersAntwerp Maritime Academy, Noordkasteel Oost 6, 2030 Antwerp, Belgium.ORCID 0000-0002-8924-3169
Kateryna L RudnievaKyiv Regional Clinical Hospital, 1 Baggovutivska Street, 04107 Kiev, Ukraine.ORCID 0000-0002-7834-233X
Svitlana Y RymarBiofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine.
Ivan V SemenyutaV. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine.
Andrew J SpiersSchool of Applied Sciences, Abertay University, Bell Street, Dundee DD1 1HG, UK.ORCID 0000-0003-0463-8629
Oksana P TarasyukV. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine.ORCID 0000-0002-7825-9720
Sergiy P RogalskyV. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine.ORCID 0000-0002-5200-5247
Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar · UANational Academy of Sciences of Ukraine · UAKyiv City Clinical Oncology Center · UAAbertay University · GBShupyk National Healthcare University of Ukraine · UAUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The choice of effective biocides used for routine hospital practice should consider the role of disinfectants in the maintenance and development of local resistome and how they might affect antibiotic resistance gene transfer within the hospital microbial population. Currently, there is little understanding of how different biocides contribute to eDNA release that may contribute to gene transfer and subsequent environmental retention. Here, we investigated how different biocides affect the release of eDNA from mature biofilms of two opportunistic model strains

Indexed as

Anti-Infective AgentsBiofilmsDisinfectantsDNA, BacterialGuanidinesNucleic Acid ConformationPseudomonas aeruginosaStaphylococcus aureusStructure-Activity RelationshipAnti-Infective AgentsDisinfectantsDNA, BacterialGuanidinespolyhexamethyleneguanidinealcoholsantibiotic resistancebiocidesbiofilmsdisinfectanteDNAhydrogen peroxidepolyhexamethylene guanidinequaternary ammonium compounds

Identifiers

PMID35054915
PMCPMC8775615
OpenAlexW4226240453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.