Evidence map›Paper›PMID 35054908›Full record

ArticleInternational journal of molecular sciences2022

Structural and Functional Characterization of Four Novel Fibrinogen Mutations in

Eliška Ceznerová, Jiřina Kaufmanová, Žofie Sovová, Jana Štikarová, Jan Loužil, Roman Kotlín, Jiří Suttnar

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. [Advances in the genetics of venous thromboembolic disease].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024
    Review
  3. Article
  4. [Phenotype and genotype analyses of two pedigrees with inherited fibrinogen deficiency].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023
    Article
  5. Fibrinogen BOE II: dysfibrinogenemia with bleeding and defective thrombin binding.Research and practice in thrombosis and haemostasis · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eliška CeznerováDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.ORCID 0000-0002-1072-5967
Jiřina KaufmanováDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic.ORCID 0000-0003-0337-8204
Žofie SovováDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.ORCID 0000-0003-3337-321X
Jana ŠtikarováDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.ORCID 0000-0002-5964-0526
Jan LoužilDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.
Roman KotlínDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.
Jiří SuttnarDepartment of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 2094/1, 12800 Prague, Czech Republic.ORCID 0000-0003-4305-9718
Institute of Haematology and Blood Transfusion · CZUniversity of Chemistry and Technology, Prague · CZ

Funding

The Ministry of Health of the Czech Republic 00023736
6 · The paper itself

Abstract

Congenital fibrinogen disorders are caused by mutations in genes coding for fibrinogen and may lead to various clinical phenotypes. Here, we present a functional and structural analysis of 4 novel variants located in the

Indexed as

Genetic Predisposition to DiseaseMutationPhenotypeAdolescentAfibrinogenemiaAgedBlood CoagulationBlood Coagulation TestsDNA Mutational AnalysisFemaleFibrinogenGenetic Association StudiesHumansInfant, NewbornMaleMiddle AgedFGB protein, humanFibrinogenafibrinogenemiacongenital fibrinogen disorderdysfibrinogenemiaFGBfunctional assayshomology modelinghypofibrinogenemiascanning electron microscopy

Identifiers

PMID35054908
PMCPMC8775743
OpenAlexW4205254756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.