Evidence map›Paper›PMID 35054898›Full record

ArticleInternational journal of molecular sciences2022

Systematic Screening of Penetratin's Protein Targets by Yeast Proteome Microarrays.

Pramod Shah, Chien-Sheng Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Designed Multifunctional Peptides for Intracellular Targets.Antibiotics (Basel, Switzerland) · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Pramod ShahInstitute of Systems Biology and Bioinformatics, Department of Biomedical Sciences and Engineering, College of Health Sciences and Technology, National Central University, Jhongli 300, Taiwan.ORCID 0000-0002-7298-2221
Chien-Sheng ChenInstitute of Systems Biology and Bioinformatics, Department of Biomedical Sciences and Engineering, College of Health Sciences and Technology, National Central University, Jhongli 300, Taiwan.ORCID 0000-0002-2372-324X
Fu Jen Catholic University · TWNational Central University · TW

Funding

Taiwan Ministry of Science and Technology (MOST) MOST 108-2320-B-006-038-MY3
6 · The paper itself

Abstract

Cell-penetrating peptides (CPPs) have distinct properties to translocate across cell envelope. The key property of CPPs to translocation with attached molecules has been utilized as vehicles for the delivery of several potential drug candidates that illustrate the significant effect in in-vitro experiment but fail in in-vivo experiment due to selectively permeable nature of cell envelop. Penetratin, a well-known CPP identified from the third α-helix of Antennapedia homeodomain of Drosophila, has been widely used and studied for the delivery of bioactive molecules to treat cancers, stroke, and infections caused by pathogenic organisms. Few studies have demonstrated that penetratin directly possesses antimicrobial activities against bacterial and fungal pathogens; however, the mechanism is unknown. In this study, we have utilized the power of high-throughput

Indexed as

Cell-Penetrating PeptidesProteomeAmino Acid SequenceAntimicrobial Cationic PeptidesComputational BiologyGene OntologyHigh-Throughput Screening AssaysProtein Array AnalysisProtein BindingProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntimicrobial Cationic PeptidesCell-Penetrating PeptidespenetratinProteomeSaccharomyces cerevisiae Proteinsantifungal activityantimicrobial peptide (AMP)cell penetrating peptide (CPP)high-throughput screeningpenetratinproteome microarraytarget identification

Identifiers

PMID35054898
PMCPMC8775591
OpenAlexW4205501122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.