Evidence map›Paper›PMID 35054849›Full record

ArticleInternational journal of molecular sciences2022

Next Generation Sequencing Detects Premeiotic Errors in Human Oocytes.

Harita Ghevaria, Sioban SenGupta, Roy Naja, Rabi Odia, Holly Exeter, Paul Serhal, Xavier Viñals Gonzalez, Xuhui Sun, Joy Delhanty

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Total whole-arm chromosome losses predict malignancy in human cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Aneuploidy detection in pooled polar bodies using rapid nanopore sequencing.Journal of assisted reproduction and genetics · 2024
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Harita GhevariaPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.ORCID 0000-0003-4781-0062
Sioban SenGuptaPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.
Roy NajaPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.
Rabi OdiaEmbryology Department, The Centre for Reproductive and Genetic Health, London W1W 5QS, UK.
Holly ExeterEmbryology Department, The Centre for Reproductive and Genetic Health, London W1W 5QS, UK.
Paul SerhalClinical Department, The Centre for Reproductive and Genetic Health, London W1W 5QS, UK.
Xavier Viñals GonzalezPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.
Xuhui SunPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.
Joy DelhantyPreimplantation Genetics Group, Institute for Women's Health, University College London (UCL), London WC1E 6HX, UK.
University College London · GBMRC Centre for Reproductive Health · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal aneuploidy is the leading cause of embryonic and foetal death in humans. This arises mainly from errors in meiosis I or II of oogenesis. A largely ignored source of error stems from germinal mosaicism, which leads to premeiotic aneuploidy. Molecular cytogenetic studies employing metaphase fluorescence

Indexed as

High-Throughput Nucleotide SequencingAdultAneuploidyHumansIn Vitro Oocyte Maturation TechniquesMeiosisOocytesYoung Adulthuman oocytesmeiosismetaphase II oocyte and first polar body complexnext generation sequencingpremeiotic aneuploidy

Identifiers

PMID35054849
PMCPMC8776218
OpenAlexW4205463825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.