Evidence map›Paper›PMID 35054834›Full record

ArticleInternational journal of molecular sciences2022

CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.

Laís Reis-das-Mercês, Tatiana Vinasco-Sandoval, Rafael Pompeu, Aline Cruz Ramos, Ana K M Anaissi, Samia Demachki, Paulo Pimentel de Assumpção, Amanda F Vidal, Ândrea Ribeiro-Dos-Santos, Leandro Magalhães

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. An Integrated TCN-CrossMHA Model for Predicting circRNA-RBP Binding Sites.Interdisciplinary sciences, computational life sciences · 2025
    Article
  6. Article
  7. Gastric Cancer in the Era of Epigenetics.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Laís Reis-das-MercêsLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.ORCID 0000-0002-8495-1422
Tatiana Vinasco-SandovalLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.
Rafael PompeuLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.
Aline Cruz RamosCenter of Oncology Research, Federal University of Pará, Belem 66073-000, PA, Brazil.
Ana K M AnaissiCenter of Oncology Research, Federal University of Pará, Belem 66073-000, PA, Brazil.ORCID 0000-0002-0636-7124
Samia DemachkiCenter of Oncology Research, Federal University of Pará, Belem 66073-000, PA, Brazil.
Paulo Pimentel de AssumpçãoCenter of Oncology Research, Federal University of Pará, Belem 66073-000, PA, Brazil.
Amanda F VidalLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.ORCID 0000-0003-4180-9925
Ândrea Ribeiro-Dos-SantosLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.ORCID 0000-0001-7001-1483
Leandro MagalhãesLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, Brazil.
Universidade Federal do Pará · BR

Funding

Antagomirs e Mimics como Ferramentas Biotecnológicas na Terapêutica do Câncer Gástrico MCTI/CNPq/Universal 14/2014 - No. 457672/2014-5CNPq/Produtividade 304413/2015-1Rede de Pesquisa em Genômica Populacional Humana Biocomputacional-Protocol No. 3381/2013/CAPES
6 · The paper itself

Abstract

Gastric cancer (GC) is the fifth most common type of cancer and the third leading cause of cancer death in the world. It is a disease that encompasses a variety of molecular alterations, including in non-coding RNAs such as circular RNAs (circRNAs). In the present study, we investigated hsa_circ_0000211, hsa_circ_0000284, hsa_circ_0000524, hsa_circ_0001136 and hsa_circ_0004771 expression profiles using RT-qPCR in 71 gastric tissue samples from GC patients (tumor and tumor-adjacent samples) and volunteers without cancer. In order to investigate the suitability of circRNAs as minimally invasive biomarkers, we also evaluated their expression profile through RT-qPCR in peripheral blood samples from patients with and without GC (

Indexed as

Gene Regulatory NetworksBiomarkers, TumorCase-Control StudiesEarly Detection of CancerGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, CircularRNA-SeqStomach NeoplasmsBiomarkers, TumorMicroRNAsRNA, CircularbiomarkercircRNAepigeneticsgastric cancermicroRNARBP

Identifiers

PMID35054834
PMCPMC8776217
OpenAlexW4205946600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.