Evidence map›Paper›PMID 35054774›Full record

ArticleInternational journal of molecular sciences2022

A Complexed Crystal Structure of a Single-Stranded DNA-Binding Protein with Quercetin and the Structural Basis of Flavonol Inhibition Specificity.

En-Shyh Lin, Ren-Hong Luo, Cheng-Yang Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Cytotoxicity and Multi-Enzyme Inhibition ofPlants (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Effects of Flavonoids and Phenols fromPlants (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Crystal Structure of an SSB Protein fromInternational journal of molecular sciences · 2022
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

En-Shyh LinDepartment of Beauty Science, National Taichung University of Science and Technology, No. 193, Sec.1, San-Min Rd., Taichung City 403, Taiwan.ORCID 0000-0002-7010-4062
Ren-Hong LuoSchool of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Cheng-Yang HuangSchool of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWNational Taichung University of Science and Technology · TW

Funding

Chung Shan Medical University CSMU-INT-109-01the Ministry of Science and Technology, Taiwan MOST 110-2622-E-025-003
6 · The paper itself

Abstract

Single-stranded DNA (ssDNA)-binding protein (SSB) plays a crucial role in DNA replication, repair, and recombination as well as replication fork restarts. SSB is essential for cell survival and, thus, is an attractive target for potential antipathogen chemotherapy. Whether naturally occurring products can inhibit SSB remains unknown. In this study, the effect of the flavonols myricetin, quercetin, kaempferol, and galangin on the inhibition of

Indexed as

Bacterial ProteinsCrystallography, X-RayDNA-Binding ProteinsFlavonoidsFlavonolsKaempferolsModels, MolecularProtein ConformationPseudomonas aeruginosaQuercetinBacterial ProteinsDNA-Binding ProteinsFlavonoidsFlavonolsgalanginkaempferolKaempferolsmyricetinQuercetinflavonolmyricetinOB-foldPriAPriBprimosomePseudomonas aeruginosaquercetinreplication forkSSB

Identifiers

PMID35054774
PMCPMC8775380
OpenAlexW4205983766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.