ArticlePolymers2022
Biocompatible and Thermoresistant Hydrogels Based on Collagen and Chitosan.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Application of hydrogels in 3D tumor microenvironment modeling and drug screening for cervical cancer: A review.Bioengineering & translational medicine · 2026Review
- Chitosan-Based Hydrogels in Vascular Tissue Engineering Applications.Materials (Basel, Switzerland) · 2026Review
- Multi-Component 3D Bioprinted Platform with Sacrificial Matrix and Collagen-Based Bioinks for Skeletal Muscle Tissue Engineering.Polymers · 2026Article
- Innovative advances and future perspectives in injectable hydrogels for wound healing: a comprehensive review.Biomedical engineering online · 2026Review
- Combination of Collagen-Chitosan Hydrogel and Injectable Platelet-Rich Fibrin as a Biomaterial for Bone Regeneration: Characterization and Growth Factor Release Pattern.European journal of dentistry · 2026Article
- Multiscale Engineering of Ion-Conducting Gels for Sustainable Bioelectronic Systems.Small methods · 2026Review
- Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds.International journal of pharmaceutics: X · 2025Review
- Advancement in Scaffold-Based 3D Cell Culture Models for Osteosarcoma Drug Screening.ACS biomaterials science & engineering · 2025Review
- Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.Gels (Basel, Switzerland) · 2025Article
- Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications.Polymers · 2025Review
- An overview of thermosensitive hydrogel based nanocomposites for high temperature and fire resistance applications.iScience · 2025Review
- Optimization of Dye and Plasticizer Concentrations in Halochromic Sensor Films for Rapid pH Response Using Bird-Inspired Metaheuristic Algorithms.Sensors (Basel, Switzerland) · 2025Article
- Article
- Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs.Marine drugs · 2025Review
- Applications of Hydrogels in Emergency Therapy.Gels (Basel, Switzerland) · 2025Review
- Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration.Frontiers in nutrition · 2025Review
- Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships.npj biomedical innovations · 2025Review
- [Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Injectable Hydrogels in Cardiovascular Tissue Engineering.Polymers · 2024Review
- Unveiling the Impact of Gelation Temperature on the Rheological and Microstructural Properties of Type A Gelatin Hydrogels.Polymers · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hydrogels are considered good biomaterials for soft tissue regeneration. In this sense, collagen is the most used raw material to develop hydrogels, due to its high biocompatibility. However, its low mechanical resistance, thermal stability and pH instability have generated the need to look for alternatives to its use. In this sense, the combination of collagen with another raw material (i.e., polysaccharides) can improve the final properties of hydrogels. For this reason, the main objective of this work was the development of hydrogels based on collagen and chitosan. The mechanical, thermal and microstructural properties of the hydrogels formed with different ratios of collagen/chitosan (100/0, 75/25, 50/50, 25/75 and 0/100) were evaluated after being processed by two variants of a protocol consisting in two stages: a pH change towards pH 7 and a temperature drop towards 4 °C. The main results showed that depending on the protocol, the physicochemical and microstructural properties of the hybrid hydrogels were similar to the unitary system depending on the stage carried out in first place, obtaining FTIR peaks with similar intensity or a more porous structure when chitosan was first gelled, instead of collagen. As a conclusion, the synergy between collagen and chitosan improved the properties of the hydrogels, showing good thermomechanical properties and cell viability to be used as potential biomaterials for Tissue Engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.